Mortality before hospital discharge · very preterm or very low birth weight infants
Slow showed no clear difference in mortality before hospital discharge compared with faster rates of enteral feed advancement (moderate certainty).
1 finding from 1 review
Feed intolerance · very preterm or very low birth weight infants
Slow may leads to higher feed intolerance before hospital discharge compared with faster rates of enteral feed advancement (low certainty).
1 finding from 1 review
Invasive infection (before hospital discharge) · very preterm or very low birth weight infants
Slow showed no clear difference in invasive infection before hospital discharge compared with faster rates of enteral feed advancement (low certainty).
1 finding from 1 review
Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm infants with PDA
Paracetamol showed no clear difference in failure of PDA closure after first course of treatment (assessed by… compared with indomethacin (low certainty).
1 finding from 1 review
All‐cause mortality during hospital stay · preterm infants with PDA
Paracetamol showed no clear difference in all‐cause mortality during initial hospital stay (by clinical… compared with indomethacin (low certainty).
1 finding from 1 review
Necrotizing enterocolitis during initial hospital stay (by radiological diagnosis) · preterm infants with PDA
Paracetamol may leads to lower necrotizing enterocolitis during initial hospital stay (by… compared with indomethacin (low certainty).
1 finding from 1 review
Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm infants with PDA
Prophylactic administration of paracetamol may leads to lower failure of PDA closure after first course (assessed by… compared with placebo or no intervention (low certainty).
1 finding from 1 review
All‐cause mortality during hospital stay · preterm infants with PDA
Prophylactic administration of paracetamol showed no clear difference in all‐cause mortality during initial hospital stay (by clinical… compared with placebo or no intervention (low certainty).
1 finding from 1 review
Necrotizing enterocolitis during initial hospital stay (by radiological diagnosis) · preterm infants with PDA
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Failure to close a patent ductus arteriosus (after 3 doses) · preterm infants with patent ductus arteriosus
The intervention probably leads to lower failure to close a patent ductus arteriosus (after 3 doses) (moderate certainty).
1 finding from 1 review
Intervention not reported
Need for surgical closure of the PDA · preterm infants with patent ductus arteriosus
The intervention showed no clear difference in need for surgical closure of the PDA (low certainty).
1 finding from 1 review
Intervention not reported
Necrotising enterocolitis (any stage) · preterm infants with patent ductus arteriosus
The intervention may leads to lower necrotising enterocolitis (any stage) (low certainty).
1 finding from 1 review
Intervention not reported
Serum/plasma creatinine levels (µmol/L) · preterm infants with patent ductus arteriosus
It is very uncertain whether the intervention changes serum/plasma creatinine levels (µmol/L) (very low certainty).
1 finding from 1 review
Intervention not reported
Failure to close a patent ductus arteriosus (after single or 3 doses) · preterm infants with patent ductus arteriosus
The intervention probably leads to lower failure to close a patent ductus arteriosus (after single or 3 doses) (moderate certainty).
1 finding from 1 review
Intervention not reported
Need for surgical closure of the ductus · preterm infants with patent ductus arteriosus
The intervention showed no clear difference in need for surgical closure of the ductus (moderate certainty).
1 finding from 1 review
Intervention not reported
Duration of ventilatory support · preterm infants with patent ductus arteriosus
The intervention showed no clear difference in duration of ventilatory support (low certainty).
1 finding from 1 review
Intervention not reported
Serum/plasma creatinine levels (μmol/L) after treatment Normal values for male and female newborns 17.7 to 88.4 µmol/L · preterm infants with patent ductus arteriosus
The intervention showed no clear difference in serum/plasma creatinine levels (μmol/L) after treatment Normal… (low certainty).
1 finding from 1 review
Intervention not reported
Oliguria (Urine output < 1 mL/kg/hour) · preterm infants with patent ductus arteriosus
The intervention showed no clear difference in oliguria (Urine output < 1 mL/kg/hour) (low certainty).
1 finding from 1 review
Intervention not reported
Failure to close a patent ductus arteriosus after 3 doses of ibuprofen · preterm infants with patent ductus arteriosus
The intervention probably leads to lower failure to close a patent ductus arteriosus after 3 doses of ibuprofen (moderate certainty).
1 finding from 1 review
Intervention not reported
Necrotising enterocolitis · preterm infants with patent ductus arteriosus
The intervention showed no clear difference in necrotising enterocolitis (low certainty).
1 finding from 1 review