Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

236 questions · 242 findings · 34 reviews · Headline outcomes only

No studies found 85 · 35.1%GRADE not reported 4 · 1.7%Very low 58 · 24%Low 52 · 21.5%Moderate 36 · 14.9%High 7 · 2.9%

Azelaic acid vs clindamycin

Participants' global self‐assessment of acne improvement Good or very good improvement (long term: treatment duration > 8 weeks) · participants with acne

Azelaic acid showed no clear difference in participants' global self‐assessment of acne improvement Good or… compared with clindamycin (low certainty).

1 finding from 1 review

Intervention not reported

Duration of diarrhoea · children with acute diarrhoea

The intervention showed no clear difference in duration of diarrhoea (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events (vomiting) · children aged less than 6 months with acute diarrhoea

The intervention probably leads to higher adverse events (vomiting) (moderate certainty).

1 finding from 1 review

Intervention not reported

Duration of diarrhoea · children with persistent diarrhoea

The intervention showed no clear difference in duration of diarrhoea (moderate certainty).

1 finding from 1 review

Intervention not reported

Diarrhoea on day 7 · children with persistent diarrhoea

The intervention showed no clear difference in diarrhoea on day 7 (low certainty).

1 finding from 1 review

Intervention not reported

Hospitalization · children with persistent diarrhoea
1 finding from 1 review

Intervention not reported

Death · children with persistent diarrhoea
1 finding from 1 review

Intervention not reported

Adverse events (vomiting) · children with persistent diarrhoea

It is very uncertain whether the intervention changes adverse events (vomiting) (very low certainty).

1 finding from 1 review

Intervention not reported

Diarrhoea on day 7 · children with acute diarrhoea

The intervention probably leads to lower diarrhoea on day 7 (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of children hospitalized (community trials only) · children with acute diarrhoea
1 finding from 1 review

Intervention not reported

Death · children with acute diarrhoea

It is very uncertain whether the intervention changes death (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events (vomiting) · children with acute diarrhoea

The intervention probably leads to higher adverse events (vomiting) (moderate certainty).

1 finding from 1 review

Intervention not reported

Duration of diarrhoea · children aged less than 6 months with acute diarrhoea

The intervention showed no clear difference in duration of diarrhoea (low certainty).

1 finding from 1 review

Intervention not reported

Diarrhoea on day 7 · children aged less than 6 months with acute diarrhoea

The intervention showed no clear difference in diarrhoea on day 7 (low certainty).

1 finding from 1 review

Intervention not reported

Number of children hospitalized (community trials only) · children aged less than 6 months with acute diarrhoea
1 finding from 1 review

Intervention not reported

Death · children aged less than 6 months with acute diarrhoea

It is very uncertain whether the intervention changes death (very low certainty).

1 finding from 1 review

Intervention not reported

Improvement in tinnitus severity and disability, measured by a validated tinnitus‐specific questionnaire (THQ) Proportion of patients improved 4 months · adults over 18 years with tinnitus
1 finding from 1 review

Intervention not reported

Adverse effects of treatment · adults over 18 years with tinnitus

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Quality of life · adults over 18 years with tinnitus

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Socioeconomic impact associated with work · adults over 18 years with tinnitus

The review found no eligible studies for this question.

1 finding from 1 review