Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

229 questions · 231 findings · 28 reviews

No studies found 32 · 13.9%GRADE not reported 3 · 1.3%Very low 28 · 12.1%Low 58 · 25.1%Moderate 60 · 26%High 50 · 21.6%

Intervention not reported

Attitudes or beliefs (Different measures used by the studies: perceived severity of vaccine‐preventable diseases, perceived necessity of vaccines, or a combination, on varying scales) Final time point (3 or 6 months post‐intervention) · parents of preschool‐aged children or expectant parents
1 finding from 1 review

Intervention not reported

Acute exacerbations (number of exacerbations/person/year) · adults (> 18 years of age) with either COPD or recurrent acute exacerbations of chronic bronchitis

The intervention showed no clear difference in acute exacerbations (number of exacerbations/person/year) (low certainty).

1 finding from 1 review

Intervention not reported

Mortality (deaths during trial period) · adults (> 18 years of age) with either COPD or recurrent acute exacerbations of chronic bronchitis

It is very uncertain whether the intervention changes mortality (deaths during trial period) (very low certainty).

1 finding from 1 review

Intervention not reported

Antibiotic prescriptions (number of courses/person/year) **Corticosteroids not meta‐analysed · adults (> 18 years of age) with either COPD or recurrent acute exacerbations of chronic bronchitis

The intervention may leads to higher antibiotic prescriptions (number of courses/person/year)… (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events (number of adverse events/person/year) · adults (> 18 years of age) with either COPD or recurrent acute exacerbations of chronic bronchitis

The intervention showed no clear difference in adverse events (number of adverse events/person/year) (low certainty).

1 finding from 1 review

Viral influenza vaccine vs control

Infant death (up to 175 days) · Pregnant women aged 18 to 38 years and an estimated gestation of 20 to 36 weeks.

Viral influenza vaccine showed no clear difference in infant death (up to 175 days) compared with control (moderate certainty).

1 finding from 1 review

Viral influenza vaccine vs control

Perinatal death (stillbirth + death in first week of life) · Pregnant women aged 18 to 38 years and an estimated gestation of 20 to 36 weeks.

Viral influenza vaccine showed no clear difference in perinatal death (stillbirth + death in first week of life) compared with control (moderate certainty).

1 finding from 1 review