Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

592 questions · 604 findings · 53 reviews · Headline outcomes only

No studies found 151 · 25%GRADE not reported 31 · 5.1%Very low 94 · 15.6%Low 170 · 28.1%Moderate 114 · 18.9%High 44 · 7.3%

Intervention not reported

Overall survival: 5‐year survival rate · stages I to III NSCLC patients treated with surgery or radiotherapy with curative intent

The intervention showed no clear difference in overall survival: 5‐year survival rate (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events: severe, grade > 2 (Duration of · stages I to III NSCLC patients treated with surgery or radiotherapy with curative intent

The intervention showed no clear difference in adverse events: severe, grade > 2 (Duration of (low certainty).

1 finding from 1 review

Hyperbaric oxygen vs air breathing to enhance the effectiveness of radiotherapy

Failure of local tumour control ‐ not reported · People undergoing radiation therapy for head and neck cancer

Hyperbaric oxygen probably leads to lower failure of local tumour control (local control) compared with air breathing to enhance the effectiveness of radiotherapy (moderate certainty).

1 finding from 1 review

Probiotics vs other active intervention

Grade ≥ 3 diarrhoea · participants with cancer treated with radiotherapy (with or without chemotherapy)

Probiotics may leads to lower severity of diarrhoea: grade 3 or higher compared with other active treatment (low certainty).

1 finding from 1 review