Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

624 questions · 782 findings · 62 reviews

No studies found 13 · 1.7%GRADE not reported 657 · 84%Very low 76 · 9.7%Low 23 · 2.9%Moderate 13 · 1.7%High 0 · 0%

3-month school-based supervised daily tooth-brushing program with fluoridated toothpaste (multilevel: trained school nurses plus parental involvement) vs Pre-intervention

Visible plaque and oral-hygiene behavior · Schoolchildren aged 4-6 years in the United Arab Emirates (Dubai)

One pre-post study of a school-based supervised tooth-brushing program found visible plaque fell from 76.8% to 36.7% with positive behavior change (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Restorative dental treatment under general anesthesia vs Before treatment (before-after)

Oral health-related quality of life (child and family) · Preschool children in the United Arab Emirates receiving dental general anesthesia

One study found restorative dental treatment under general anesthesia significantly improved oral health-related quality of life for preschool children and their families (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Younger children's age (3-5 years) vs Older children (>5 years)

Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years

Children aged 3 years had higher odds of poor OHRQoL than older children (OR 2.00, 95% CI 1.42-2.57; 2 studies; ungraded).

2 findings from 1 review

Intraglandular botulinum neurotoxin (BoNT) injection vs No BoNT (placebo or pre-treatment baseline)

Salivary pH · Patients with drooling (sialorrhea) due to neurological disease

BoNT injections were not associated with significant changes in oral/salivary pH across three studies (ungraded; no effect estimate reported).

1 finding from 1 review
  • Oral health effects of botulinum toxin treatment for drooling: a systematic review. 2020 All outcomes
    Before vs after BoNT injection · Neurological-disease populations with drooling (e.g., cerebral palsy, Parkinson disease, adults with sialorrhea); specialist clinical care
    Wu et al. did not observe significant differences in participants' oral pH before and after BoNT-A injections between the active and control groups. There were also no statistically significant differences regarding…
    3 studies
    GRADE not reported

All exposure-OHRQoL estimates pooled for publication-bias correction (meta-trim sensitivity); specific exposure set not defined in source vs Not specified

Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years

A trim-and-fill sensitivity analysis pooling every exposure estimate gave an overall OR of 0.17 (95% CI 0.13-0.21) after correcting for significant publication bias (Fig. 13); this combined estimate spans heterogeneous exposures and is a publication-bias sensitivity result (ungraded).

1 finding from 1 review

Periodontal disease (present) vs Individuals without periodontal disease (by LOA)

Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years

Periodontal disease was associated with higher odds of poor OHRQoL (OR 1.15, 95% CI 1.12-1.18; 3 studies; no heterogeneity; ungraded).

1 finding from 1 review

Higher dental caries experience vs Caries-free controls

Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years

Higher dental caries experience was associated with substantially higher odds of poor OHRQoL (OR 1.66, 95% CI 1.43-1.88; 6 studies; high heterogeneity I2=83.5%; ungraded).

1 finding from 1 review

Low maternal education (<=6 years of schooling) vs Higher maternal education (>6 years)

Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years

Lower maternal education was associated with poor OHRQoL (OR 1.12, 95% CI 1.00-1.23; 4 studies; high heterogeneity; CI lower bound at the null; ungraded).

1 finding from 1 review

Orthodontic treatment need vs No orthodontic treatment need

Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years

Orthodontic treatment need was associated with modestly higher odds of poor OHRQoL (OR 1.13, 95% CI 1.07-1.18; 3 studies; ungraded).

1 finding from 1 review

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

Oral ulcerations · Children and adolescents with juvenile idiopathic arthritis (JIA)

A single study reported more oral ulcerations in children with JIA (5/41) than without JIA (1/41); evidence is limited to one study (ungraded).

1 finding from 1 review

Higher JIA disease activity/severity (e.g., high JADAS/activity scores, polyarticular RF-negative subtype, active disease, anti-TNFalpha or cyclosporine medication) vs Lower JIA disease activity / inactive or milder JIA

Prevalence and severity of oral and TMJ diseases/conditions (periodontal status and dental caries) · Children and adolescents with juvenile idiopathic arthritis (JIA)

Some studies suggested greater JIA disease activity/severity (and certain medications) was associated with worse periodontal and caries outcomes, but small samples meant no solid conclusion could be drawn (ungraded).

1 finding from 1 review

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

Oral health-related quality of life · Children and adolescents with juvenile idiopathic arthritis (JIA)

Evidence on OHRQoL was limited: one study found no significant difference between groups while another found orofacial symptoms affected daily life more in JIA; no pooled estimate (ungraded).

1 finding from 1 review

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

Plaque index (PI) / oral hygiene · Children and adolescents with juvenile idiopathic arthritis (JIA)

Evidence on oral hygiene/dental plaque was inconsistent: several studies found higher plaque in the JIA group while others found no difference; no pooled estimate (ungraded).

1 finding from 1 review

Secondary education vs University education

Prevalence of fair/poor self-rated oral health · Adults aged 25 years and older in Australia, Canada, New Zealand, and the United States

In United States, secondary versus university education differed by 27.5 percentage points in prevalence of fair/poor self-rated oral health.

4 findings from 1 review
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Primary education vs University education

Prevalence of fair/poor self-rated oral health · Adults aged 25 years and older in Australia, Canada, New Zealand, and the United States

In New Zealand, primary versus university education differed by 17.59 percentage points in prevalence of fair/poor self-rated oral health.

5 findings from 1 review
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Medium income vs High income

Prevalence of fair/poor self-rated oral health · Adults aged 25 years and older in Australia, Canada, New Zealand, and the United States

In Canada, medium versus high income differed by 8.3 percentage points in prevalence of fair/poor self-rated oral health.

4 findings from 1 review
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