Findings

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Evidence found and GRADE certainty

237 questions · 355 findings · 28 reviews · Oral Health

No studies found 26 · 7.3%GRADE not reported 273 · 76.9%Very low 39 · 11%Low 13 · 3.7%Moderate 4 · 1.1%High 0 · 0%

Radiographic caries detection (bitewing radiography) vs Reference standard (histological validation or cavity/lesion opening; advanced = cavitated/dentin-involved lesions, all = enamel-confined initial lesions also counted)

PPV for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)

In the German private-practice setting, the positive predictive value of radiographic detection for all (initial and advanced) occlusal caries was 22.6% at an assumed prevalence of 11.0% (ungraded).

2 findings from 1 review

Visual caries detection (ICDAS visual/visual-tactile inspection) vs Reference standard (histological validation or cavity/lesion opening; advanced = cavitated/dentin-involved lesions, all = enamel-confined initial lesions also counted)

NPV for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)

In the German private-practice setting, the negative predictive value of visual detection for advanced occlusal caries was 85.9% at an assumed prevalence of 22.0% (ungraded).

2 findings from 1 review

Visual caries detection (ICDAS visual/visual-tactile inspection) vs Reference standard (histological validation or cavity/lesion opening; advanced = cavitated/dentin-involved lesions, all = enamel-confined initial lesions also counted)

Positive LR for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)

In the meta-analysis tailored to Egypt, the positive lr of visual detection for all (initial and advanced) occlusal caries was 3.73 (95% CI 3.1 to 4.4) (ungraded).

3 findings from 1 review

Radiographic caries detection (bitewing radiography) vs Reference standard (histological validation or cavity/lesion opening; advanced = cavitated/dentin-involved lesions, all = enamel-confined initial lesions also counted)

PPV for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)

In the Egyptian public health clinic setting, the positive predictive value of radiographic detection for advanced occlusal caries was 58.3% at an assumed prevalence of 19.0% (ungraded).

2 findings from 1 review

Visual caries detection (ICDAS visual/visual-tactile inspection) vs Reference standard (histological validation or cavity/lesion opening; advanced = cavitated/dentin-involved lesions, all = enamel-confined initial lesions also counted)

PPV for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)

In the German private-practice setting, the positive predictive value of visual detection for all (initial and advanced) occlusal caries was 82.0% at an assumed prevalence of 45.0% (ungraded).

2 findings from 1 review

Radiographic caries detection (bitewing radiography) vs Reference standard (histological validation or cavity/lesion opening; advanced = cavitated/dentin-involved lesions, all = enamel-confined initial lesions also counted)

Sensitivity for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)

In the meta-analysis tailored to Germany, pooled sensitivity of radiographic detection for all (initial and advanced) occlusal caries was 36.0% (95% CI 20 to 56) (ungraded).

3 findings from 1 review

Radiographic caries detection vs Reference standard (often histological; also invasive opening)

All proximal carious lesions · Permanent molar surfaces in diagnostic accuracy studies (mostly in vitro; clinical)

Pooled specificity for radiographic detection of all proximal lesions was 0.900 (95% CI 0.87 to 0.92).

1 finding from 1 review

Visual caries detection (ICDAS visual/visual-tactile inspection) vs Reference standard (histological validation or cavity/lesion opening; advanced = cavitated/dentin-involved lesions, all = enamel-confined initial lesions also counted)

Sensitivity for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)

In the meta-analysis tailored to Germany, pooled sensitivity of visual detection for advanced occlusal caries was 43.7% (95% CI 37 to 51) (ungraded).

3 findings from 1 review

Biofunctional Prosthetic System (BPS): closed-mouth two stage-two step final impression with addition silicone elastomer vs Conventional complete denture technique (CCD): open-mouth two stage-two step conventional technique using elastomer

Participant-reported quality of the denture (general satisfaction) · Completely edentulous people
1 finding from 1 review

Biofunctional Prosthetic System (BPS): closed-mouth two stage-two step final impression with addition silicone elastomer vs Conventional complete denture technique (CCD): open-mouth two stage-two step conventional technique using elastomer

Participant preference for dentures · Completely edentulous people
1 finding from 1 review

Arthroscopy vs open surgery

Tenderness on palpation in jaw muscles (clinical evaluation, 12 months) · Adults (older than 18 years) with a temporomandibular disorder (synovitis, disc displacement with or without reduction, myofascial…

Arthroscopy showed no clear difference in tenderness on palpation in jaw muscles (clinical evaluation, 12… compared with open surgery; GRADE not reported.

1 finding from 1 review

Arthroscopy vs open surgery

Tenderness on palpation in TMJ (clinical evaluation, 12 months) · Adults (older than 18 years) with a temporomandibular disorder (synovitis, disc displacement with or without reduction, myofascial…

Arthroscopy showed no clear difference in tenderness on palpation in TMJ (clinical evaluation, 12 months) compared with open surgery; GRADE not reported.

1 finding from 1 review

Arthroscopy vs open surgery

Maximum protrusion over 5 mm (clinical evaluation, 12 months) · Adults (older than 18 years) with a temporomandibular disorder (synovitis, disc displacement with or without reduction, myofascial…

Arthroscopy showed no clear difference in maximum protrusion over 5 mm (clinical evaluation, 12 months) compared with open surgery; GRADE not reported.

1 finding from 1 review

Arthroscopy vs open surgery

Clinical evaluations 12 months after surgery (6 pooled clinical signs) · Adults (older than 18 years) with a temporomandibular disorder (synovitis, disc displacement with or without reduction, myofascial…

Arthroscopy showed no clear difference in clinical evaluations 12 months after surgery (6 pooled clinical signs) compared with open surgery; GRADE not reported.

1 finding from 1 review

Arthroscopy vs open surgery

Pain (VAS/SSI) after 12 months · Adults (older than 18 years) with a temporomandibular disorder (synovitis, disc displacement with or without reduction, myofascial…

Arthroscopy led to higher pain (VAS/SSI) after 12 months compared with open surgery; GRADE not reported.

1 finding from 1 review

Arthroscopy vs open surgery

Crepitation (clinical evaluation, 12 months) · Adults (older than 18 years) with a temporomandibular disorder (synovitis, disc displacement with or without reduction, myofascial…

Arthroscopy showed no clear difference in crepitation (clinical evaluation, 12 months) compared with open surgery; GRADE not reported.

1 finding from 1 review

Arthroscopy vs open surgery

Click (clinical evaluation, 12 months) · Adults (older than 18 years) with a temporomandibular disorder (synovitis, disc displacement with or without reduction, myofascial…

Arthroscopy showed no clear difference in click (clinical evaluation, 12 months) compared with open surgery; GRADE not reported.

1 finding from 1 review

Arthroscopy vs open surgery

Mandibular functionality (MFIQ) after 12 months · Adults (older than 18 years) with a temporomandibular disorder (synovitis, disc displacement with or without reduction, myofascial…

Arthroscopy showed no clear difference in mandibular functionality (MFIQ) after 12 months compared with open surgery; GRADE not reported.

1 finding from 1 review

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Sites failing to gain 2 mm attachment (proportion) · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

Guided tissue regeneration (GTR) with barrier membrane (resorbable… led to lower sites failing to gain 2 mm attachment (proportion) compared with open flap debridement (access flap surgery); GRADE not reported.

1 finding from 1 review