What do systematic reviews say?

Erbium:YAG laser vs Air-abrasive device (Perio-Flow)

Er:YAG laser showed no clear difference in radiographic marginal bone level change compared with air-abrasive device (Perio-Flow); GRADE not reported.

• Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes

  6 months
  After 6 months no statistically significant difference for peri-implant marginal bone levels.
  1 study · 42 participants
  GRADE not reported

Povidone vs Water

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  no estimate extracted
  2 studies
  GRADE not reported

Immediate implants (placed in a fresh extraction socket just after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Immediate implants (placed in a fresh extraction socket just after… showed no clear difference in perimplant marginal bone level changes compared with delayed implants (placed at least 2 months after extraction, in…; GRADE not reported.

• Interventions for replacing missing teeth: dental implants in fresh extraction sockets (immediate, immediate‐delayed… 2010 · Cochrane All outcomes

  1 year
  No statistically significant differences for perimplant marginal bone level changes at 1 year (Lindeboom 2006).
  1 study · 50 participants
  GRADE not reported

Autogenous bone block from the chin vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Autogenous bone block from the chin showed no clear difference in prosthesis/implant failure (1 year) compared with 100% Bio-Oss + resorbable barrier; GRADE not reported.

• Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental implant… 2009 · Cochrane All outcomes

  Up to 1 year post-loading
  OR 0.19 [0.01, 4.07]
  1 study · 62 participants
  GRADE not reported

Horizontal bone augmentation (any technique) vs No augmentation

The review found no eligible studies for this question.

• Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental implant… 2009 · Cochrane All outcomes

  At least to abutment connection (planned)
  No trial evaluated whether horizontal bone augmentation is necessary (explicit gap)
  0 studies
  No studies found

Autogenous bone block from the chin + resorbable barrier vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Autogenous bone block from the chin + resorbable barrier showed no clear difference in prosthesis/implant failure (1 year) compared with 100% Bio-Oss + resorbable barrier; GRADE not reported.

• Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental implant… 2009 · Cochrane All outcomes

  Up to 1 year post-loading
  OR 0.19 [0.01, 4.07]
  1 study · 62 participants
  GRADE not reported

Prednisone vs placebo

Prednisone showed no clear difference in oral mucositis (any severity) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 1.03 [0.85, 1.24]
  1 study · 66 participants
  GRADE not reported

Prednisone vs placebo

Prednisone showed no clear difference in oral mucositis (severe) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.64 [0.17, 2.45]
  1 study · 66 participants
  GRADE not reported

Prednisone vs placebo

Prednisone showed no clear difference in oral mucositis (moderate to severe) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.71 [0.47, 1.07]
  1 study · 66 participants
  GRADE not reported

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… led to higher severe pain for > 1 week compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

• Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental implant… 2009 · Cochrane All outcomes

  3 weeks post-surgery
  OR 22.67 [4.37, 117.47]
  1 study · 40 participants
  GRADE not reported

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… showed no clear difference in experienced the operation negatively compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

• Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental implant… 2009 · Cochrane All outcomes

  3 weeks post-surgery
  OR 3.0 [0.79, 11.44]
  1 study · 40 participants
  GRADE not reported

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… led to lower no improvement of facial appearance (3 weeks) compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

• Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental implant… 2009 · Cochrane All outcomes

  3 weeks post-surgery
  OR 0.11 [0.03, 0.46]
  1 study · 40 participants
  GRADE not reported

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… showed no clear difference in prosthetic failure compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

• Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental implant… 2009 · Cochrane All outcomes

  Up to 2 years post-loading
  OR 3.20 [0.48, 21.25]
  2 studies · 98 participants
  GRADE not reported

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… led to higher major complications compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

• Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental implant… 2009 · Cochrane All outcomes

  Up to 2 years post-loading
  OR 4.97 [1.10, 22.40]
  2 studies · 100 participants
  GRADE not reported

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… showed no clear difference in implant failure compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

• Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental implant… 2009 · Cochrane All outcomes

  Up to 2 years post-loading
  OR 5.74 [0.92, 35.82]
  2 studies · 98 participants
  GRADE not reported

Brief motivational interviewing (BMI) vs usual treatment alone

Brief one-session, manual-guided discussion based on the principles… led to lower alcohol consumption: consuming more than 21 units of alcohol per week compared with treatment at the outpatient clinic as usual; GRADE not reported.

• One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes

  12 months
  RR 0.52 [0.32, 0.85]
  1 study · 151 participants
  GRADE not reported

One-to-one advice on sugar restriction: detailed information on the sugar content of foods, with instruction to refrain from sugar-containing foods between meals and to reduce sugar in main meals (6-week sugar restriction) vs No advice on sugar restriction

• One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes

  Follow-up at 3, 6 and 12 weeks
  Table 5, mean (SD) intakes/day between meals: intervention 6.7 (1.9) baseline, 0.8 (1.0) at 3 weeks, 0.9 (1.0) at 6 weeks, 5.6 (3.0) at 12 weeks; control 5.3 (2.3), 5.2 (2.9), 4.6 (3.5), 4.7 (1.5). Significant…
  1 study · 20 participants
  GRADE not reported

One-to-one advice on sugar restriction: detailed information on the sugar content of foods, with instruction to refrain from sugar-containing foods between meals and to reduce sugar in main meals (6-week sugar restriction) vs No advice on sugar restriction

• One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes

  Follow-up at 3, 6 and 12 weeks
  Table 5, mean (SD) intakes/day at main meals: intervention 2.8 (0.5) baseline, 0.7 (0.7) at 3 weeks, 0.8 (0.9) at 6 weeks, 2.3 (0.8) at 12 weeks; control 1.9 (1.1), 1.9 (1.2), 1.9 (1.1), 2.0 (0.9). Significant…
  1 study · 20 participants
  GRADE not reported

One-to-one advice on sugar restriction: detailed information on the sugar content of foods, with instruction to refrain from sugar-containing foods between meals and to reduce sugar in main meals (6-week sugar restriction) vs No advice on sugar restriction

• One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes

  Follow-up at 3, 6 and 12 weeks
  Table 5, total mean (SD) intakes/day: intervention 9.5 (1.9) baseline, 1.6 (1.4) at 3 weeks, 1.8 (1.5) at 6 weeks, 7.8 (3.5) at 12 weeks; control 7.2 (2.6), 7.1 (3.7), 6.5 (4.2), 6.7 (2.2). Significant reduction versus…
  1 study · 20 participants
  GRADE not reported

Dental extraction protocol with plasma rich in growth factors (PRGF) inserted into the postextraction alveolus vs Standard dental extraction protocol without PRGF

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  24 to 60 months
  No intraoperative complications were observed in either of the groups.
  1 study · 176 participants
  GRADE not reported