Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

493 questions · 506 findings · 45 reviews

No studies found 137 · 27.1%GRADE not reported 26 · 5.1%Very low 101 · 20%Low 135 · 26.7%Moderate 78 · 15.4%High 29 · 5.7%

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Dental caries prevalence and severity · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in dental caries/severity between ART regimens (very low certainty).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Angular cheilitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No eligible studies compared angular cheilitis between different ART regimens.

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Recurrent oral ulceration prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in recurrent oral ulceration between ART regimens (very low certainty).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Dental development and maturation · Children and adolescents (<18 years) living with HIV (CLWH)

No eligible studies compared dental development and maturation between different ART regimens.

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Acute necrotising ulcerative periodontitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in acute necrotising ulcerative periodontitis between ART regimens (very low certainty).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Kaposi's sarcoma prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in kaposi's sarcoma between ART regimens (very low certainty).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Linear gingival erythema prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in linear gingival erythema between ART regimens (very low certainty).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Chronic herpes simplex infection prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in chronic herpes simplex infection between ART regimens (very low certainty).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Oral hairy leukoplakia prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No eligible studies compared oral hairy leukoplakia between different ART regimens.

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Gingivitis · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in gingivitis between ART regimens (very low certainty).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

cART was associated with a significantly lower prevalence of oral candidiasis than monotherapy or dual therapy (very low certainty).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Persistent parotid enlargement prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in persistent parotid enlargement between ART regimens (very low certainty).

1 finding from 1 review