Findings

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Evidence found and GRADE certainty

1,078 questions · 1,098 findings · 33 reviews · Skin

No studies found 396 · 36.1%GRADE not reported 89 · 8.1%Very low 181 · 16.5%Low 183 · 16.7%Moderate 196 · 17.9%High 53 · 4.8%

Oral miltefosine (1.2 to 3.3 mg/kg/d 28 days) vs meglumine antimoniate (20 mg/kg 20 days)

Adverse effects (number of participants who had the event) · People with American cutaneous and mucocutaneous leishmaniasis

Oral miltefosine (1.2 to 3.3 mg/kg/d 28 days) probably leads to higher adverse effects (number of participants who had the event) compared with meglumine antimoniate (20 mg/kg 20 days) (moderate certainty).

1 finding from 1 review

IFN‐α + PUVA vs PUVA

Improvement of quality of life · people with mycosis fungoides

The review found no eligible studies for this question.

1 finding from 1 review

Bexarotene + PUVA vs PUVA

Common adverse effects ‐ Photosensitivity (Time point of measurement: up to 16 weeks) · people with mycosis fungoides

Bexarotene + PUVA showed no clear difference in common adverse effects ‐ Photosensitivity (Time point of… compared with PUVA alone (low certainty).

1 finding from 1 review

Bexarotene + PUVA vs PUVA

Complete response · people with mycosis fungoides

Bexarotene + PUVA showed no clear difference in complete response (Time point of measurement: up to 16 weeks) compared with PUVA alone (low certainty).

1 finding from 1 review

Bexarotene + PUVA vs PUVA

Objective response rate · people with mycosis fungoides

Bexarotene + PUVA showed no clear difference in objective response rate (Time point of measurement: up to 16 weeks) compared with PUVA alone (low certainty).

1 finding from 1 review

IFN‐α + acitretin vs IFN‐α + PUVA

Adverse event (flu‐like symptoms) · people with mycosis fungoides

IFN‐α + acitretin showed no clear difference in common adverse effects ‐ Flu‐like symptoms (Time point of… compared with IFN‐α + PUVA (low certainty).

1 finding from 1 review

IFN‐α + acitretin vs IFN‐α + PUVA

Complete response · people with mycosis fungoides

IFN‐α + acitretin may leads to lower complete response (Time point of measurement: up to 48 weeks or… compared with IFN‐α + PUVA (low certainty).

1 finding from 1 review

IFN‐α + PUVA vs PUVA

Complete response · people with mycosis fungoides

IFN‐α + PUVA showed no clear difference in complete response (CR) compared with PUVA alone (low certainty).

1 finding from 1 review

Extracorporeal photopheresis vs PUVA

Complete response · people with mycosis fungoides

It is very uncertain whether extracorporeal photopheresis changes complete response (Time point of measurement: three months of PUVA… compared with PUVA (very low certainty).

1 finding from 1 review