Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

289 questions · 326 findings · 19 reviews · Drugs and Alcohol

No studies found 13 · 4%GRADE not reported 33 · 10.1%Very low 108 · 33.1%Low 109 · 33.4%Moderate 52 · 16%High 11 · 3.4%

Tricyclic antidepressants vs placebo

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether tricyclic antidepressants changes benzodiazepine discontinuation, end of intervention compared with placebo (very low certainty).

1 finding from 1 review