Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

233 questions · 238 findings · 33 reviews

No studies found 31 · 13%GRADE not reported 5 · 2.1%Very low 74 · 31.1%Low 92 · 38.7%Moderate 36 · 15.1%High 0 · 0%

Endometrial injury vs control

Miscarriage per woman randomised (studies at low risk of selection bias and other bias) · women undergoing assisted reproduction

Endometrial injury showed no clear difference in miscarriage per woman randomised (studies at low risk of selection… compared with control (moderate certainty).

1 finding from 1 review

Endometrial injury vs control

Miscarriage · women undergoing assisted reproduction

Endometrial injury showed no clear difference in miscarriage per woman randomised: sensitivity analysis (no high risk) compared with control (low certainty).

2 findings from 1 review

Endometrial injury vs control

Clinical pregnancy · women undergoing assisted reproduction

Endometrial injury showed no clear difference in clinical pregnancy per woman randomised (studies at low risk of… compared with control (moderate certainty).

2 findings from 1 review

Endometrial injury vs control

Clinical pregnancy per woman randomised: sensitivity analysis (no high‐risk) · women undergoing assisted reproduction

Endometrial injury showed no clear difference in clinical pregnancy per woman randomised: sensitivity analysis (no… compared with control (low certainty).

1 finding from 1 review

Metformin vs placebo or no treatment

Clinical pregnancy rate · women with polycystic ovary syndrome

It is very uncertain whether metformin changes clinical pregnancy rate per woman ‐ short protocol GnRH‐antagonist compared with placebo or no treatment (very low certainty).

1 finding from 1 review · compare the 2 reviews

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Live birth rate per woman · for controlled ovarian stimulation

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in live birth per woman compared with gonadotropins (with GnRH agonists or midcycle antagonist) (low certainty).

1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Ovarian Hyperstimulation Syndrome rate per woman ‐ not reported · for controlled ovarian stimulation

Clomiphene citrate or letrozole with or without gonadotropins (with… may leads to lower ovarian hyperstimulation syndrome per woman compared with gonadotropins (with GnRH agonists or midcycle antagonist) (low certainty).

1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · for controlled ovarian stimulation

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in clinical pregnancy rate per woman compared with gonadotropins (with GnRH agonists or midcycle antagonist) (moderate certainty).

1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Cancellation rate per woman · for controlled ovarian stimulation

Clomiphene citrate or letrozole with or without gonadotropins (with… may leads to higher cancellation rate per woman compared with gonadotropins (with GnRH agonists or midcycle antagonist) (low certainty).

1 finding from 1 review