Findings

What do systematic reviews say?

207 questions · 224 findings · 22 reviews · Vascular

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No studies found 42 · 18.8%GRADE not reported 21 · 9.4%Very low 33 · 14.7%Low 81 · 36.2%Moderate 35 · 15.6%High 12 · 5.4%

Intervention not reported

Occlusion of catheter within one week of catheter insertion · Children with central venous catheter

The intervention showed no clear difference in occlusion of catheter within one week of catheter insertion (low certainty).

1 finding from 1 review

Heparin‐bonded catheters for prolonging the patency of central venous catheters in children 2014 · Cochrane Headline outcomes only
RR 0.06 [0, 1.07]
1 study · 200 participants
Low

Intervention not reported

Catheter‐related blood stream infection and CVC‐related colonization · Children with central venous catheter

The intervention may leads to lower catheter‐related blood stream infection and CVC‐related colonization (low certainty).

1 finding from 1 review

Heparin‐bonded catheters for prolonging the patency of central venous catheters in children 2014 · Cochrane Headline outcomes only
RR 0.06 [0.01, 0.41]
1 study · 200 participants
Low

Intervention not reported

Side effects: Thrombocytopenia after catheter insertion · Children with central venous catheter

The intervention showed no clear difference in side effects: Thrombocytopenia after catheter insertion (low certainty).

1 finding from 1 review

Heparin‐bonded catheters for prolonging the patency of central venous catheters in children 2014 · Cochrane Headline outcomes only
RR 0.73 [0.38, 1.39]
2 studies · 287 participants
Low

Direct thrombin inhibitors vs vitamin K antagonist (VKA)

Major VTE events in TKR combined doses bilateral ascending venography · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in major VTE events in TKR combined doses bilateral ascending venography compared with vitamin K antagonists (low certainty).

1 finding from 1 review

Direct thrombin inhibitors versus vitamin K antagonists or low molecular weight heparins for prevention of venous… 2010 · Cochrane Headline outcomes only
OR 0.85 [0.63, 1.15]
3 studies · 4327 participants
Low

Direct thrombin inhibitors vs vitamin K antagonist (VKA)

All‐cause Mortality events in TKR combined doses · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in all‐cause Mortality events in TKR combined doses compared with vitamin K antagonists (low certainty).

1 finding from 1 review

Direct thrombin inhibitors versus vitamin K antagonists or low molecular weight heparins for prevention of venous… 2010 · Cochrane Headline outcomes only
OR 1.62 [0.57, 4.58]
3 studies · 5243 participants
Low

Direct thrombin inhibitors vs vitamin K antagonist (VKA)

Total Bleeding events in TKR combined doses · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in total Bleeding events in TKR combined doses compared with vitamin K antagonists (low certainty).

1 finding from 1 review

Direct thrombin inhibitors versus vitamin K antagonists or low molecular weight heparins for prevention of venous… 2010 · Cochrane Headline outcomes only
OR 1.26 [0.97, 1.62]
3 studies · 5259 participants
Low

Direct thrombin inhibitors vs vitamin K antagonist (VKA)

ALT >3 times the upper normal limit · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in ALT >3 times the upper normal limit at the end of compared with vitamin K antagonists (low certainty).

1 finding from 1 review

Direct thrombin inhibitors versus vitamin K antagonists or low molecular weight heparins for prevention of venous… 2010 · Cochrane Headline outcomes only
OR 5.61 [1, 31.64]
2 studies · 4267 participants
Low