Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

229 questions · 612 findings · 24 reviews

No studies found 6 · 1%GRADE not reported 568 · 92.8%Very low 24 · 3.9%Low 10 · 1.6%Moderate 4 · 0.7%High 0 · 0%

Salvadora persica (miswak) mouthrinse vs Pre-treatment (baseline, same group)

Streptococcus mutans count · Medically healthy individuals (adults and children, 6-60 years)

Salvadora persica rinse reduced Streptococcus mutans counts relative to baseline; not GRADE-rated.

1 finding from 1 review

Salvadora persica (miswak) mouthrinse vs Placebo rinse

Streptococcus mutans count · Medically healthy individuals (adults and children, 6-60 years)

Salvadora persica rinse reduced Streptococcus mutans counts more than placebo (favours Salvadora persica); not GRADE-rated.

1 finding from 1 review

Salvadora persica (miswak) mouthrinse vs Placebo rinse

Plaque · Medically healthy individuals (adults and children, 6-60 years)

Salvadora persica rinse reduced plaque more than placebo (favours Salvadora persica); certainty not GRADE-rated (Shekelle grade Ia).

1 finding from 1 review

Chlorhexidine 0.12% mouthrinse vs Pre-treatment (baseline, same group)

Plaque · Medically healthy individuals (adults and children, 6-60 years)

0.12% chlorhexidine rinse reduced plaque relative to baseline; not GRADE-rated.

1 finding from 1 review

Salvadora persica (miswak) mouthrinse vs Pre-treatment (baseline, same group)

Plaque · Medically healthy individuals (adults and children, 6-60 years)

Salvadora persica rinse reduced plaque relative to its own baseline; not GRADE-rated.

1 finding from 1 review

Placebo rinse vs Pre-treatment (baseline, same group)

Streptococcus mutans count · Medically healthy individuals (adults and children, 6-60 years)

Placebo rinse did not significantly change Streptococcus mutans counts relative to baseline; not GRADE-rated.

1 finding from 1 review

Chlorhexidine 0.2% vs Pre-treatment (baseline, same group)

Plaque · Medically healthy individuals (adults and children, 6-60 years)

0.2% chlorhexidine rinse reduced plaque relative to baseline; not GRADE-rated.

1 finding from 1 review

Fluoride toothpaste vs Not applicable (single-group prevalence)

Fluoride toothpaste use prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries

About 39% of children with caries in LMICs used fluoride toothpaste (pooled prevalence 0.391, 95% CI 0.166 to 0.644; 2 studies; not GRADE-rated).

1 finding from 1 review

Maternal education attainment vs Children without dental caries

Dental caries (association with no formal maternal education) · Children (deciduous and/or permanent dentition) in low- and middle-income countries

No formal maternal education showed a non-significant trend toward higher odds of dental caries (OR 1.34, 95% CI 0.76 to 2.36; 3 studies; not GRADE-rated).

1 finding from 1 review

Socioeconomic status category vs Children without dental caries

Dental caries · Children (deciduous and/or permanent dentition) in low- and middle-income countries

High SES showed no significant association with dental caries (OR 1.03, 95% CI 0.81 to 1.31; 5 studies; not GRADE-rated).

2 findings from 1 review

Good brushing habits (>=2 daily tooth brushing) vs Children without dental caries

Dental caries · Children (deciduous and/or permanent dentition) in low- and middle-income countries

Good brushing habits (>=2 daily) were associated with 35% lower odds of dental caries (OR 0.65, 95% CI 0.46 to 0.92; 7 studies; not GRADE-rated).

1 finding from 1 review

Maternal education attainment vs Children without dental caries

Dental caries (association with secondary/higher maternal education) · Children (deciduous and/or permanent dentition) in low- and middle-income countries

Secondary/higher maternal education showed no significant association with dental caries (OR 0.96, 95% CI 0.64 to 1.44; 7 studies; not GRADE-rated).

1 finding from 1 review

Caregiver help with child tooth brushing vs Not applicable (single-group prevalence)

Caregiver help with tooth brushing prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries

About 54% of children with caries in LMICs received caregiver help with tooth brushing (pooled prevalence 0.541, 95% CI 0.266 to 0.803; 3 studies; not GRADE-rated).

1 finding from 1 review

Female sex vs Not applicable (single-group prevalence)

Female sex prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries

Among children with caries in LMICs, about half were female (pooled prevalence 0.497, 95% CI 0.475 to 0.519; 6 studies; I2=0%; not GRADE-rated).

1 finding from 1 review

Sugary drinks/sweets consumption vs Not applicable (single-group prevalence)

Sugary drinks/sweets consumption prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries

About 70% of children with caries in LMICs consumed sugary drinks/sweets (pooled prevalence 0.697, 95% CI 0.478 to 0.877; 7 studies; very high heterogeneity; not GRADE-rated).

1 finding from 1 review

Maternal education attainment vs Children without dental caries

Dental caries (association with primary maternal education) · Children (deciduous and/or permanent dentition) in low- and middle-income countries

Primary maternal education was associated with 25% higher odds of dental caries (OR 1.25, 95% CI 1.02 to 1.54; 7 studies; not GRADE-rated).

1 finding from 1 review

Socioeconomic status category vs Children without dental caries

Dental caries (association with middle SES) · Children (deciduous and/or permanent dentition) in low- and middle-income countries

Middle SES showed no significant association with dental caries (OR 0.80, 95% CI 0.59 to 1.10; 7 studies; not GRADE-rated).

1 finding from 1 review

Socioeconomic status category vs Not applicable (single-group prevalence)

Low SES prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries

About 36% of children with caries in LMICs were of low SES (pooled prevalence 0.359, 95% CI 0.167 to 0.578; 4 studies; not GRADE-rated).

1 finding from 1 review

Dental caries assessment (WHO/clinical diagnostic criteria; caries = DMFT>0) vs None (descriptive prevalence; random-effects pooled proportion)

Dental caries prevalence · Children (deciduous and/or permanent dentition) in low- and middle-income countries

About 39% of children in LMICs had dental caries (pooled prevalence 0.387, 95% CI 0.284 to 0.495; 11 studies; very high heterogeneity I2=99%; not GRADE-rated).

1 finding from 1 review