Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

509 questions · 521 findings · 45 reviews

No studies found 87 · 16.7%GRADE not reported 61 · 11.7%Very low 166 · 31.9%Low 120 · 23%Moderate 73 · 14%High 14 · 2.7%

ECT plus standard care vs antipsychotics plus standard care

Response to treatment (medium term) Clinically important response to treatment as defined by each study · people with treatment‐resistant schizophrenia

ECT plus standard care showed no clear difference in response to treatment (medium term) Clinically important response to… compared with antipsychotics plus standard care (low certainty).

1 finding from 1 review

Benzodiazepines vs antipsychotics

Adverse effects/events ‐ extrapyramidal symptoms ‐ medium term Number of instances of extrapyramidal symptoms · psychosis‐induced aggression or agitation

Benzodiazepines may leads to lower adverse effects/events: extrapyramidal symptoms ‐ vs haloperidol ‐… compared with antipsychotics (low certainty).

1 finding from 1 review

Benzodiazepines vs ANTIHISTAMINES + ANTIPSYCHOTICS

Tranquillisation or asleep: sedation ‐ medium term ‐ midazolam vs haloperidol + promethazineNumber of participants sedated · psychosis‐induced aggression or agitation

Benzodiazepines may leads to higher tranquillisation or asleep: sedation ‐ medium term ‐ midazolam vs… compared with antihistamines plus antipsychotics (low certainty).

1 finding from 1 review

Benzodiazepines vs ANTIHISTAMINES + ANTIPSYCHOTICS

Global state: no improvement ‐ medium termAs defined in each study · psychosis‐induced aggression or agitation

Benzodiazepines may leads to higher global state: no improvement ‐ medium termAs defined in each study compared with antihistamines plus antipsychotics (low certainty).

1 finding from 1 review

Benzodiazepines vs ANTIHISTAMINES + ANTIPSYCHOTICS

Global impression ‐ need for additional medication ‐ medium term Number of participants requiring additional medication · psychosis‐induced aggression or agitation

Benzodiazepines showed no clear difference in global state: need for additional medication ‐ medium termNumber of… compared with antihistamines plus antipsychotics (low certainty).

1 finding from 1 review