Findings

What do systematic reviews say?

4,411 questions · 5,986 findings · 226 reviews · Oral Health

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No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Activator functional appliance vs Prefabricated functional myobrace appliance (PFA)

Final overjet · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

Activator functional appliance showed no clear difference in final overjet compared with prefabricated functional myobrace appliance (PFA); GRADE not reported.

1 finding from 1 review

Orthodontic treatment for prominent upper front teeth (Class II malocclusion) in children and adolescents 2018 · Cochrane All outcomes
End of orthodontic treatment
MD -0.6 [-1.63, 0.43]
1 study · 97 participants
GRADE not reported

4% prilocaine plain vs 2% lidocaine, 1:100,000 epinephrine

Speed of onset of anaesthesia · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
SoF: Not measured.
0 studies
No studies found

4% articaine, 1:100,000 epinephrine vs 2% mepivacaine, 1:100,000 epinephrine

Success of local anaesthesia (soft tissue, self-reported; 100% success in all studies) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 4% articaine, 1:100,000 epinephrine changes success of local anaesthesia (soft tissue, self-reported) compared with 2% mepivacaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
RR 1.07 [0.73, 1.59]
2 studies · 68 participants
Very low

4% articaine plain vs 4% articaine, 1:100,000 epinephrine

Success of local anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 4% articaine plain changes success of local anaesthesia (pulpal, electric pulp tester; healthy… compared with 4% articaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
RR 0.61 [0.38, 0.97]
2 studies · 134 participants
Very low

Enhanced one-to-one OHA vs Routine one-to-one OHA

Probing pocket depth · Children or adults (fit and healthy, or with a well-defined medical condition)

1 finding from 1 review

One‐to‐one oral hygiene advice provided in a dental setting for oral health 2018 · Cochrane All outcomes
Bali 1999 (probing depths) and Soderholm 1982 (pocket depths > 5 mm); measured but not synthesised or GRADE-rated.
2 studies
GRADE not reported

Biofunctional Prosthetic System (BPS): closed-mouth two stage-two step final impression with addition silicone elastomer vs Conventional complete denture technique (CCD): open-mouth two stage-two step conventional technique using elastomer

Oral health-related quality of life · Completely edentulous people

1 finding from 1 review

Final‐impression techniques and materials for making complete and removable partial dentures 2018 · Cochrane All outcomes
3 months
OHIP-EDENT median scores: BPS 34.5; CCD 35.8. No clear difference between groups
1 study · 10 participants
Very low

Self-management (self-administered/self-monitored OHA) vs Professional OHA

Probing pocket depth · Children or adults (fit and healthy, or with a well-defined medical condition)

1 finding from 1 review

One‐to‐one oral hygiene advice provided in a dental setting for oral health 2018 · Cochrane All outcomes
Jonsson 2006 (probing depth) and Lopez-Jornet 2014 (CPITN score); measured but not synthesised or GRADE-rated.
2 studies
GRADE not reported

R-appliance vs Anterior inclined bite plate (AIBP)

Final ANB · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

R-appliance showed no clear difference in final ANB compared with anterior inclined bite plate (AIBP); GRADE not reported.

1 finding from 1 review

Orthodontic treatment for prominent upper front teeth (Class II malocclusion) in children and adolescents 2018 · Cochrane All outcomes
End of orthodontic treatment
MD -0.3 [-0.99, 0.39]
1 study · 50 participants
GRADE not reported

HP strips vs HP gel in tray

Adverse effects · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

1 finding from 1 review

Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
Tooth sensitivity and oral irritation mild and transient and did not differ between groups
2 studies
GRADE not reported

Zinc oxide and eugenol (ZOE) vs Ozonated sesame oil-zinc oxide (ZO)

Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth

The review found no eligible studies for this question.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
Listed as a pulpectomy comparison; no extractable outcome data reported in this version
0 studies
No studies found

Diode laser vs Ferric sulphate (FS)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Diode laser showed no clear difference in radiological failure compared with ferric sulphate (FS) (low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 0.89 [0.38, 2.12]
3 studies · 130 participants
Low

Hydroxyzine vs Different dosage/timing of hydroxyzine

Behaviour · Children and adolescents (0 to 16 years) needing dental treatment

1 finding from 1 review

Sedation of children undergoing dental treatment 2018 · Cochrane All outcomes
Any behavioural score - Hydroxyzine: 30 (1 study); VERY LOW. Insufficient evidence to determine whether any specific dose of hydroxyzine is effective.
1 study · 30 participants
Very low

SPT provided at one time interval vs SPT provided at a different time interval

Outcome not reported · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)

The review found no eligible studies for this question.

1 finding from 1 review

Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Bleeding duration (minutes, all types of bleeding, minor and major) · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…

The review found no eligible studies for this question.

1 finding from 1 review

Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or… 2018 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

4% articaine, 1:200,000 epinephrine vs 0.5% bupivacaine, 1:200,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

2 findings from 1 review

Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
SoF: See comment (orphan study; unclear whether data relate to just solution deposition; SDs not reported); 18 participants, 36 interventions (1 study). Not pooled/graded.
1 study · 18 participants
GRADE not reported
Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
SoF: Not measured.
0 studies
No studies found

Supportive periodontal therapy (SPT) including mechanical debridement vs Monitoring only, or alternative interventions that do not include mechanical debridement

Outcome not reported · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)

The review found no eligible studies for this question.

1 finding from 1 review

Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

14% HP strip vs placebo

Oral health-related quality of life · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

1 finding from 1 review

Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
No significant impact of tooth whitening on OHRQoL (Bruhn 2012; Wong 2004)
2 studies
GRADE not reported

Meperidine (intramuscular) vs placebo or no intervention

Good or better behaviour · Children and adolescents (0 to 16 years) needing dental treatment

Meperidine (intramuscular) may leads to higher good or better behaviour compared with placebo (including no intervention) (low certainty).

1 finding from 1 review

Sedation of children undergoing dental treatment 2018 · Cochrane All outcomes
RR 5.33 [1.45, 19.64]
1 study · 60 participants
Low

Electrosurgery vs Ferric sulphate (FS)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Electrosurgery showed no clear difference in clinical failure compared with ferric sulphate (FS) (low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 0.56 [0.13, 2.34]
2 studies · 50 participants
Low

14% HP strip vs 9.5% HP gel in tray

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

It is very uncertain whether 14% HP strip changes tooth whitening - assessed by the dentist compared with 9.5% HP gel in tray (very low certainty).

1 finding from 1 review

Home‐based chemically‐induced whitening (bleaching) of teeth in adults 2018 · Cochrane All outcomes
22 days
MD -1.40 [-2.35, -0.45]
1 study · 29 participants
Very low