Findings

What do systematic reviews say?

2,511 questions · 2,668 findings · 290 reviews

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No studies found 743 · 27.8%GRADE not reported 329 · 12.3%Very low 775 · 29%Low 484 · 18.1%Moderate 279 · 10.5%High 58 · 2.2%

Modified B‐Lynch compression suture technique vs standard B‐Lynch compression suture (one uterine compression suture technique versus another uterine compression suture technique)

Hysterectomy to control bleeding · women with uncontrolled atonic PPH following caesarean section, and not responding to standard care (uterine massage, ecbolics and…

Modified B‐Lynch compression suture technique may leads to lower hysterectomy to control bleeding compared with standard B‐Lynch compression suture (one uterine compression suture… (low certainty).

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
RR 0.33 [0.11, 0.99]
1 study · 160 participants
Low

External uterine compression (all methods) plus normal care vs normal care

Blood transfusion (red cell or whole blood) · women diagnosed with primary PPH following vaginal birth. PPH was defined as quote: "blood loss > 500mL after delivery" p 601

It is very uncertain whether external uterine compression (all methods) plus normal care changes blood transfusion (red cell or whole blood) compared with normal care (very low certainty).

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
RR 2.33 [0.66, 8.23]
1 study · 64 participants
Very low

Modified B‐Lynch compression suture technique vs standard B‐Lynch compression suture (one uterine compression suture technique versus another uterine compression suture technique)

Serious maternal morbidity (renal or respiratory failure, cardiac arrest or multiple organ failure) · women with uncontrolled atonic PPH following caesarean section, and not responding to standard care (uterine massage, ecbolics and…

The review found no eligible studies for this question.

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Modified B‐Lynch compression suture technique vs standard B‐Lynch compression suture (one uterine compression suture technique versus another uterine compression suture technique)

Number of women with total blood loss 1000 mL or more after randomisation · women with uncontrolled atonic PPH following caesarean section, and not responding to standard care (uterine massage, ecbolics and…

The review found no eligible studies for this question.

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Modified B‐Lynch compression suture technique vs standard B‐Lynch compression suture (one uterine compression suture technique versus another uterine compression suture technique)

Mean blood loss (mL) (trialist defined) · women with uncontrolled atonic PPH following caesarean section, and not responding to standard care (uterine massage, ecbolics and…

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Modified B‐Lynch compression suture technique vs standard B‐Lynch compression suture (one uterine compression suture technique versus another uterine compression suture technique)

Blood transfusion (red cell or whole blood) · women with uncontrolled atonic PPH following caesarean section, and not responding to standard care (uterine massage, ecbolics and…

The review found no eligible studies for this question.

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Modified B‐Lynch compression suture technique vs standard B‐Lynch compression suture (one uterine compression suture technique versus another uterine compression suture technique)

Side effects of the intervention (e.g. trauma, necrosis) · women with uncontrolled atonic PPH following caesarean section, and not responding to standard care (uterine massage, ecbolics and…

The review found no eligible studies for this question.

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

External uterine compression (all methods) plus normal care vs normal care

Side effects of the intervention (e.g. trauma, necrosis) ‐ not reported · women diagnosed with primary PPH following vaginal birth. PPH was defined as quote: "blood loss > 500mL after delivery" p 601

The review found no eligible studies for this question.

1 finding from 1 review

Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Azithromycin + SRP vs SRP

Antimicrobial resistance · Adults with periodontitis (chronic and aggressive)

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Doxycycline + SRP vs SRP

Antimicrobial resistance · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Lingual split with chisel vs Lingual split with bur

Temporary altered chin sensation · Adults with mandibular third molars requiring removal

Lingual split with chisel showed no clear difference in temporary altered chin sensation compared with lingual split with bur; GRADE not reported.

1 finding from 1 review

Surgical techniques for the removal of mandibular wisdom teeth 2020 · Cochrane All outcomes
<1 month · chisel vs bur
OR 0.24 [0.04, 1.31]
1 study · 52 participants
GRADE not reported

Doxycycline + SRP vs SRP

Adverse events · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included study has not reported adverse events
Studies not reported
No studies found

Clindamycin + SRP vs Doxycycline + SRP

Patient-reported quality of life changes · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Metronidazole + SRP vs Amoxicillin + metronidazole + SRP

Probing pocket depth · Adults with periodontitis (chronic and aggressive)

Metronidazole + SRP showed no clear difference in probing pocket depth compared with amoxicillin + metronidazole + SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.26 [-0.83, 0.31]
1 study · 22 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 0.10 [-0.12, 0.32]
3 studies · 84 participants
GRADE not reported

Metronidazole + SRP vs SRP

Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)

Metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with SRP; GRADE not reported.

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 0.04 [-0.43, 0.50]
4 studies · 108 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD -1.12 [-2.24, 0.00]
3 studies · 71 participants
Very low
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.49 [-1.29, 0.31]
4 studies · 94 participants
GRADE not reported

Clindamycin + SRP vs Metronidazole + SRP

Adverse events · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included study has not reported adverse events
Studies not reported
No studies found

Metronidazole + SRP vs Amoxicillin + metronidazole + SRP

Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive)

Metronidazole + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with amoxicillin + metronidazole + SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 4.46 [-23.48, 32.40]
3 studies · 84 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD 20.85 [3.31, 38.39]
1 study · 22 participants
GRADE not reported

Azithromycin + SRP vs SRP

Patient-reported quality of life changes · Adults with periodontitis (chronic and aggressive)

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Metronidazole + SRP vs SRP

Antimicrobial resistance · Adults with periodontitis (chronic and aggressive)

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Moxifloxacin + SRP vs SRP

Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis

Moxifloxacin + SRP led to lower percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -3.40 [-3.72, -3.08]
1 study · 40 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.80 [-1.12, -0.48]
1 study · 40 participants
GRADE not reported