Cardiovascular events: non‐fatal stroke · Adults (general population)
Summary of findings table ‐ LSSS intervention showed no clear difference in cardiovascular events: non‐fatal stroke compared with regular salt (moderate certainty).
1 finding from 1 review
Cardiovascular events: non‐fatal acute coronary syndrome (events per 100,000 person‐years) · Adults (general population)
Summary of findings table ‐ LSSS intervention probably leads to lower cardiovascular events: non‐fatal acute coronary syndrome (events per… compared with regular salt (moderate certainty).
1 finding from 1 review
Cardiovascular mortality · Adults (general population)
Summary of findings table ‐ LSSS intervention showed no clear difference in cardiovascular mortality (events per 100,000 person‐years) compared with regular salt (moderate certainty).
1 finding from 1 review
Stroke mortality (events per 100,000 person‐years) · Adults (general population)
It is very uncertain whether summary of findings table ‐ LSSS intervention changes stroke mortality (events per 100,000 person‐years) compared with regular salt (very low certainty).
1 finding from 1 review
Psychosis ‐ presented in units of NPI‐NH P (higher is worse)d ‐ 3364 persons in 12 RCTs of 3 to 12 weeks
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Response for psychosis ‐ as defined by authors of RCTs ‐ 1958 persons in 7 RCTs of 3 to 12 weeks
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Adverse effects/events ‐ extrapyramidal symptoms ‐ medium term Number of instances of extrapyramidal symptoms
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Somnolence
1 finding from 1 review
no estimate extracted
Studies not reported
High
Death ‐ 5032 persons in 17 RCTs of 3 to 12 weeks ___________________________________________
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Specific behaviour ‐ agitation
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Response for agitation ‐ as defined by authors of RCTs ‐ 1303 persons in 4 RCTs of 3 to 12 weeks
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
HRQoL ‐ all domains (change from baseline) Scale: age‐appropriate versions of the CFQ‐R questionnaire · adults, children and young people with CF
1 finding from 1 review
Lung function: FEV1 mL (change from baseline) · adults, children and young people with CF
1 finding from 1 review
FEV1 % predicted: absolute change from baseline · adults, children and young people with CF
1 finding from 1 review
FVC · adults, children and young people with CF
1 finding from 1 review
Lung function: FEF25‐75 mL/s (change from baseline) · adults, children and young people with CF
1 finding from 1 review
Adverse events relating to treatment Scale: mild, moderate, severe and total · adults, children and young people with CF
1 finding from 1 review
All‐cause mortality · people at increased risk for developing type 2 diabetes
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Metformin · people at increased risk for developing type 2 diabetes
2 findings from 1 review
Acarbose · people at increased risk for developing type 2 diabetes
2 findings from 1 review