Adverse effects: drowsiness, hypersomnia, and excessive sleepiness · otherwise healthy adults and children with common cold symptoms
Antihistamine‐decongestant showed no clear difference in adverse effects: drowsiness, hypersomnia, and excessive sleepiness compared with placebo (low certainty).
1 finding from 1 review
Adverse effects: dry mouth · otherwise healthy adults and children with common cold symptoms
Antihistamine‐decongestant leads to higher adverse effects: dry mouth compared with placebo (high certainty).
1 finding from 1 review
Adverse effects: insomnia · otherwise healthy adults and children with common cold symptoms
Antihistamine‐decongestant showed no clear difference in adverse effects: insomnia compared with placebo (moderate certainty).
1 finding from 1 review
Adverse effects: gastrointestinal upset · otherwise healthy adults and children with common cold symptoms
Antihistamine‐decongestant showed no clear difference in adverse effects: gastrointestinal upset compared with placebo (moderate certainty).
1 finding from 1 review
Global evaluation · otherwise healthy adults and children with common cold symptoms
Antihistamine‐analgesic probably leads to lower global evaluation compared with placebo (moderate certainty).
1 finding from 1 review
Adverse effects: drowsiness, hypersomnia, and excessive sleepiness · otherwise healthy adults and children with common cold symptoms
Antihistamine‐analgesic showed no clear difference in adverse effects: drowsiness, hypersomnia, and excessive sleepiness compared with placebo (low certainty).
1 finding from 1 review
Global evaluation · otherwise healthy adults and children with common cold symptoms
Analgesic‐decongestant probably leads to lower global evaluation compared with placebo (moderate certainty).
1 finding from 1 review
On‐study mortality3 (Subnet based on 55 studies including 15,074 participants) · patients at any age with solid cancer or haematological malignancy
ESA with or without iron showed no clear difference in on‐study mortality3 (Subnet based on 55 studies including 15,074… compared with no treatment (low certainty).
1 finding from 1 review
RR 0.13 [0.01, 2.29]
Studies not reported
Low
Haemoglobin response (Subnet based on 31 studies including 6985 participants) · patients at any age with solid cancer or haematological malignancy
ESA with or without iron probably leads to higher haemoglobin response (Subnet based on 31 studies including 6985… compared with no treatment (moderate certainty).
1 finding from 1 review
RR 6.71 [4.93, 9.14]
Studies not reported
Moderate
Red blood cell transfusions (Subnet based on 69 studies including 18,684 participants) · patients at any age with solid cancer or haematological malignancy
ESA with or without iron probably leads to lower red blood cell transfusions (Subnet based on 69 studies including… compared with no treatment (moderate certainty).
1 finding from 1 review
RR 0.44 [0.31, 0.63]
Studies not reported
Moderate
Overall mortality4 (Subnet based on 71 studies including 21,576 participants) · patients at any age with solid cancer or haematological malignancy
ESA with or without iron showed no clear difference in overall mortality4 (Subnet based on 71 studies including 21,576… compared with no treatment (low certainty).
1 finding from 1 review
RR 1.46 [0.87, 2.43]
Studies not reported
Low
Thromboembolic events · patients at any age with solid cancer or haematological malignancy
ESA with or without iron showed no clear difference in thromboembolic events5 (Subnet based on 50 studies including 15,408… compared with no treatment (moderate certainty).
1 finding from 1 review
RR 1.82 [0.98, 3.41]
Studies not reported
Moderate
Thrombocytopenia or haemorrhage5 (Subnet based on 13 studies including 2744 participants) · patients at any age with solid cancer or haematological malignancy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Hypertension5 (Subnet based on 24 studies including 8383 participants) · patients at any age with solid cancer or haematological malignancy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
All‐cause mortality · adults with disease‐related malnutrition
Dietary advice showed no clear difference in mortality compared with no advice (low certainty).
1 finding from 1 review
Number of people admitted or re‐admitted to hospital · adults with disease‐related malnutrition
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
All‐cause mortality · adults with disease‐related malnutrition
Dietary advice plus supplements if required showed no clear difference in mortality compared with no advice (low certainty).
1 finding from 1 review
Number of people admitted or re‐admitted to hospital · adults with disease‐related malnutrition
Dietary advice plus supplements if required showed no clear difference in number of people admitted or re‐admitted to hospital compared with no advice (moderate certainty).
1 finding from 1 review
Length of hospital stay · adults with disease‐related malnutrition
1 finding from 1 review
Complications · adults with disease‐related malnutrition
Dietary advice plus supplements if required showed no clear difference in complications compared with no advice (low certainty).
1 finding from 1 review