Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,227 questions · 2,562 findings · 156 reviews · All outcomes

No studies found 297 · 11.6%GRADE not reported 1,616 · 63.1%Very low 405 · 15.8%Low 144 · 5.6%Moderate 81 · 3.2%High 19 · 0.7%

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Number of days in hospital · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in number of days in hospital compared with placebo; GRADE not reported.

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Adverse events · Adults with cancer receiving treatment
1 finding from 1 review

Granulocyte-colony stimulating factor (G-CSF; pegfilgrastim, single dose) vs Granulocyte-colony stimulating factor (G-CSF; filgrastim, multiple doses)

Normalcy of diet (total parenteral nutrition) · Children receiving bone marrow/stem cell transplantation after conditioning therapy for mixed cancers

Granulocyte-colony stimulating factor (G-CSF; pegfilgrastim, single… showed no clear difference in normalcy of diet (total parenteral nutrition) compared with granulocyte-colony stimulating factor (G-CSF; filgrastim, multiple…; GRADE not reported.

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Retained roots (mean number) · Older people (aged 60 years or older) with dementia

Retained roots were more common in older people with dementia (0.2 to 10) than without (0.0 to 1.2); no meta-analysis was performed (ungraded).

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Caries experience (mean DMFT) · Older people (aged 60 years or older) with dementia

The DMFT index was similar between groups, with only 1 of 5 comparative studies finding a significant difference; no meta-analysis was performed (ungraded).

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Denture use (prevalence) · Older people (aged 60 years or older) with dementia

Denture use was similar in older people with and without dementia, though one study reported lower denture use with more severe dementia; no meta-analysis was performed (ungraded).

1 finding from 1 review

Granulocyte-macrophage colony-stimulating factor (GM-CSF), mouthwash vs Sucralfate mouthwash

Normalcy of diet (percutaneous endoscopic gastrostomy) · Adults receiving radiotherapy to the head and neck

Granulocyte-macrophage colony-stimulating factor (GM-CSF), mouthwash showed no clear difference in normalcy of diet (percutaneous endoscopic gastrostomy) compared with sucralfate mouthwash; GRADE not reported.

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Normalcy of diet (supplemental nutrition: TPN, PEG, nasogastric tube or IV hydration) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in normalcy of diet (supplemental nutrition: TPN, PEG, nasogastric tube… compared with placebo; GRADE not reported.

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Dental caries: prevalence of root caries · Older people (aged 60 years or older) with dementia

Root caries was higher in older people with dementia (0.6 to 4.9) than without (0.3 to 1.7), described as significantly more common but not pooled (ungraded).

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Interruptions to cancer treatment (chemotherapy delays/discontinuations) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in interruptions to cancer treatment (chemotherapy… compared with placebo; GRADE not reported.

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Interruptions to cancer treatment (unscheduled radiotherapy breaks of 5 or more days) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in interruptions to cancer treatment (unscheduled radiotherapy breaks… compared with placebo; GRADE not reported.

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Edentulousness (prevalence) · Older people (aged 60 years or older) with dementia

Edentulousness was similar in older people with and without dementia, with wide overlapping ranges across studies; no meta-analysis was performed (ungraded).

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Orofacial pain (prevalence) · Older people (aged 60 years or older) with dementia

Orofacial pain prevalence was similar in older people with dementia (7.4 to 21.7%) and without dementia (6.7 to 18.5%), based on few studies; no meta-analysis was performed (ungraded).

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Coronal caries (mean number) · Older people (aged 60 years or older) with dementia

Coronal caries was higher in older people with dementia (0.1 to 2.9) than without (0.0 to 1.0), described as significantly more common but not pooled (ungraded).

1 finding from 1 review

GM-CSF vs placebo or no treatment

Normalcy of diet (total parenteral nutrition) · Adults with cancer receiving treatment

Granulocyte-macrophage colony-stimulating factor (GM-CSF) showed no clear difference in normalcy of diet (total parenteral nutrition) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

GM-CSF vs placebo or no treatment

Number of days of treatment with opioid analgesics · Adults with cancer receiving treatment

Granulocyte-macrophage colony-stimulating factor (GM-CSF) led to lower number of days of treatment with opioid analgesics compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

G‐CSF vs placebo or no treatment

Normalcy of diet (percutaneous endoscopic gastrostomy) · Adults with cancer receiving treatment

Granulocyte-colony stimulating factor (G-CSF) showed no clear difference in normalcy of diet (percutaneous endoscopic gastrostomy) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review