Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,006 questions · 3,171 findings · 607 reviews · Headline outcomes only

No studies found 411 · 13%GRADE not reported 153 · 4.8%Very low 968 · 30.5%Low 897 · 28.3%Moderate 589 · 18.6%High 153 · 4.8%

Retinoic acid post‐consolidation therapy vs no further treatment

Event‐free survival · high‐risk neuroblastoma patients treated with autologous HSCT

Retinoic acid postconsolidation therapy showed no clear difference in event‐free survival (reported as relapse, disease progression, death… compared with no further treatment (low certainty).

1 finding from 1 review

Rapid COJEC vs standard induction therapies

Early toxicities (during preoperative chemotherapy): febrile neutropenia (2 or more episodes), proven fungal infections, septicemia (1 or more episodes), gastrointestinal toxicity (grade 3 or 4), renal toxicity (glomerular filtration rate < 80 ml/... · patients with high‐risk neuroblastoma
1 finding from 1 review

Rapid COJEC vs standard induction therapies

Late non‐hematological toxicities: any complication, renal toxicity (Glomerular Filtration Rate < 80 ml/min per body surface area of 1.73 m2), ototoxicity (Brock grade 1 to 4), endocrine complications (see table of included studies for included di... · patients with high‐risk neuroblastoma
1 finding from 1 review

Epinephrine vs epinephrine and any second endoscopic method

Recurrent and persistent bleeding overall rates with or without second‐look endoscopy Rebleeding (persistent or recurrent bleeding) · patients with high‐risk bleeding ulcers

Epinephrine probably leads to lower recurrent and persistent bleeding overall rates with or without… compared with epinephrine and any second endoscopic method (moderate certainty).

1 finding from 1 review