Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,745 questions · 4,389 findings · 203 reviews · Dental caries

No studies found 39 · 0.9%GRADE not reported 3,844 · 87.6%Very low 198 · 4.5%Low 137 · 3.1%Moderate 134 · 3.1%High 37 · 0.8%

Periodontal disease (present) vs Individuals without periodontal disease (by LOA)

Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years

Periodontal disease was associated with higher odds of poor OHRQoL (OR 1.15, 95% CI 1.12-1.18; 3 studies; no heterogeneity; ungraded).

1 finding from 1 review

CT + TT genotype (T-allele carriers) of ENAM rs3796703 vs CC genotype of ENAM rs3796703

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of ENAM rs3796703 and dental caries susceptibility (CT + TT vs CC model: OR 0.90, 95% CI 0.23-3.63); certainty not graded.

3 findings from 1 review

Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator

Absence of recurrent caries success rate · Children with primary molars requiring proximal (Class II) restorations

After trim-and-fill adjustment the absence-of-recurrent-caries success rate was 0.878 (95% CI 0.828-0.915; ungraded), a negligible change.

2 findings from 1 review

TT genotype of AMELX rs6639060 vs CC + CT genotype of AMELX rs6639060

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC + CT genotype of AMELX rs6639060 and dental caries susceptibility (TT vs CC + CT model: OR 1.00, 95% CI 0.42-2.39) in the Ethnicity: Caucasian subgroup; certainty not graded.

3 findings from 1 review

Higher dental caries experience vs Caries-free controls

Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years

Higher dental caries experience was associated with substantially higher odds of poor OHRQoL (OR 1.66, 95% CI 1.43-1.88; 6 studies; high heterogeneity I2=83.5%; ungraded).

1 finding from 1 review

Vegetarian diet (any diet excluding all meat, poultry and fish) vs Nonvegetarian diet

Caries experience (mean DMFT) · General population (children and adults) assessed for dental hard-tissue health

Among adults, the lower DMFT score in vegetarians was smaller and not statistically significant (mean difference -0.09, 95% CI -0.32 to 0.13; ungraded).

2 findings from 1 review

Fluoride varnish vs Fissure sealant (resin-based or glass ionomer)

Caries incidence of occlusal surfaces of first permanent molars · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…

After excluding Bravo 1996, occlusal caries incidence slightly favored fluoride varnish but was not significant, with heterogeneity falling to 0% (RR 0.98, 95% CI 0.82 to 1.16; 3 RCTs; ungraded).

2 findings from 1 review