Findings

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Evidence found and GRADE certainty

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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Intervention not reported

Presence of PDA on day 3 or 4 of life (after 72 hours of treatment) · preterm or low birth weight infants with risk of having PDA on day 3 to 4 of life

The intervention may leads to lower presence of PDA on day 3 or 4 of life (after 72 hours of treatment) (low certainty).

1 finding from 1 review

Intervention not reported

Time to achieve full enteral feeding (days) · preterm infants with low birth weight

The intervention showed no clear difference in time to achieve full enteral feeding (days) (low certainty).

1 finding from 1 review

Intervention not reported

Cerebral palsy at 18 to 24 months' corrected age · preterm infants with low birth weight

The intervention showed no clear difference in cerebral palsy at 18 to 24 months' corrected age (high certainty).

1 finding from 1 review

Intervention not reported

BSID‐III composite cognitive scores at 18 to 22 months The Bayley‐III has 3 main sub tests: the Cognitive Scale, which includes items such as attention to familiar and unfamiliar objects, looking for a fallen object, and pretend play; the Language... · neonates born preterm with low birth weight

The intervention probably leads to higher BSID‐III composite cognitive scores at 18 to 22 months The… (moderate certainty).

1 finding from 1 review

Intervention not reported

WPPSI‐III FSIQ at 3.5 to 4 years of age Composite scores have a mean of 100 and a standard deviation of 15. Average is 90 to 109. · neonates born preterm with low birth weight

The intervention may leads to higher WPPSI‐III FSIQ at 3.5 to 4 years of age Composite scores have a mean… (low certainty).

1 finding from 1 review

Intervention not reported

Any neurodevelopmental impairment at 18 to 22 months' corrected age (in children examined) · preterm infants with low birth weight

The intervention may leads to lower any neurodevelopmental impairment at 18 to 22 months' corrected age… (low certainty).

1 finding from 1 review

Intervention not reported

Bayley‐II MDI at 18 to 24 months Bayley Scales of Infant Development, Second Edition, yields 2 single age‐standardised composite scores (range 50 to 150): a Mental Development Index (MDI), which measures cognition through sensory perception, knowl... · preterm infants with low birth weight
1 finding from 1 review

Intervention not reported

Necrotising enterocolitis (stage not reported) · preterm infants with low birth weight

The intervention probably leads to lower necrotising enterocolitis (stage not reported) (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality during initial hospital stay (all causes of mortality) · preterm infants with low birth weight

The intervention showed no clear difference in mortality during initial hospital stay (all causes of mortality) (high certainty).

1 finding from 1 review

Intervention not reported

Retinopathy of prematurity (stage ≥ 3) · preterm infants with low birth weight

The intervention showed no clear difference in retinopathy of prematurity (stage ≥ 3) (high certainty).

1 finding from 1 review

Intervention not reported

Intraventricular haemorrhage (grades III and IV) · preterm infants with low birth weight

The intervention probably leads to lower intraventricular haemorrhage (grades III and IV) (moderate certainty).

1 finding from 1 review

Intervention not reported

Survivors at discharge from hospital without severe IVH, PVL, ROP · preterm infants with low birth weight

The intervention showed no clear difference in survivors at discharge from hospital without severe IVH, PVL, ROP (high certainty).

1 finding from 1 review

Intervention not reported

Necrotising Enterocolitis ≥ Bell's stage 2 during initial hospital stay · preterm infants with low birth weight

The intervention showed no clear difference in necrotising Enterocolitis ≥ Bell's stage 2 during initial hospital… (moderate certainty).

1 finding from 1 review

Intervention not reported

Retinopathy of prematurity (all stages or stage not reported) during initial hospital stay · preterm infants with low birth weight

It is very uncertain whether the intervention changes retinopathy of prematurity (all stages or stage not reported) during… (very low certainty).

1 finding from 1 review

Intervention not reported

Retinopathy of prematurity (stage ≥ 3) during initial hospital stay · preterm infants with low birth weight

It is very uncertain whether the intervention changes retinopathy of prematurity (stage ≥ 3) during initial hospital stay (very low certainty).

1 finding from 1 review