Development of >=1 new carious lesion (caries incidence) · Children who were regular dental attenders with caries-free first or second primary molars (public health service clinic, Brazil)
The review found no eligible studies for this question.
1 finding from 1 review
Progression of non-cavitated enamel caries · Children with sound primary molars, aged 2-4 years (municipal dental clinics or hospital paediatric clinics, Denmark)
The review found no eligible studies for this question.
1 finding from 1 review
Change in systemic antibiotic use · Residents of nursing homes and other long-term care facilities
The review found no eligible studies for this question.
1 finding from 1 review
Beta diversity and community composition · Participants in oral 16S rRNA caries microbiome studies
Beta-diversity matrices showed statistically significant ADONIS results, while clustering by study and 16S region was also observed; no pooled effect estimate was reported.
1 finding from 1 review
Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
1 finding from 1 review
At operator level, because of high heterogeneity (I2 = 89%), which could not be explained, the results were not meta-analysed (2 studies, 60 participants; Feres 2010, Retamal-Valdes 2017). No pooled estimate or GRADE…
2 studies · 60 participants
GRADE not reported
Intervention not reported
Enamel acid resistance / initiation of new enamel caries lesions (in vivo, narrative)
1 finding from 1 review
External disease-state discrimination · Oral microbiome samples from four selected case-control studies
The KEGG Orthology classifier had an approximate AUC of 0.75 in the disease-only study test set.
1 finding from 1 review
AUC 0.75
4 studies
GRADE not reported
Retention of sealant (complete or partial retention) · Children who were regular dental attenders with caries-free first or second primary molars (public health service clinic, Brazil)
1 finding from 1 review
Effect estimate not calculable. All sealants were completely or partially retained; 40 (1 RCT). Flowable composite: 39/40 completely retained (1 partially lost) at 6 months; resin-based: 33 completely and 7 partially…
1 study · 40 participants
Low
Serum high-sensitivity C-reactive protein (hs-CRP) · Patients with cardiovascular disease and chronic periodontitis
1 finding from 1 review
Serum hs-CRP tested at one year; as loss to follow-up was almost 90%, data not considered useful for analysis (no usable estimate).
1 study · 37 participants
GRADE not reported
Dental caries increment, DMFT/dmft (whole-tooth level) · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric clinic/dental school,…
1 finding from 1 review
Caries incidence of first permanent molars (FPMs) · Schoolchildren aged 6-12 years with sound occlusal surfaces of the first permanent molars
Pit and fissure sealant and fluoride varnish showed no statistically significant difference in caries incidence of first permanent molars at 24 months (RR 0.65, 95% CI 0.31 to 1.38; I2=89%; not GRADE-rated).
1 finding from 1 review
Retention of sealant (complete or partial retention) · 'Healthy' children with caries-free second primary molars, aged 3-5 years (schools and kindergartens, India and China)
1 finding from 1 review
Study-specific disease-state discrimination · Oral microbiome samples in 15 case-controlled studies
Bong-Soo 2017, Zhu 2018, and Jiang 2019 had mean AUC scores over 0.75; exact study-specific AUCs were not reported in text or readable figure labels.
1 finding from 1 review
no estimate extracted
15 studies
GRADE not reported
Adverse events · 'Healthy' children with caries-free second primary molars, aged 3-5 years (schools and kindergartens, India and China)
1 finding from 1 review
1 study reported adverse events as some discomfort such as nausea; 1 child experienced a strong gag reflex following the glass ionomer-based sealant while 8 children reported feeling uncomfortable after the fluoride…
1 study · 100 participants
Very low
Progression of non-cavitated enamel caries · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric clinic/dental school,…
The review found no eligible studies for this question.
1 finding from 1 review
Progression of non-cavitated enamel caries · Children with caries-free or non-cavitated carious lesion primary molars, aged 3-7 years (paediatric department, dental hospital, France)
The review found no eligible studies for this question.
1 finding from 1 review
Intervention not reported
Mean DMFT (decayed, missing, filled permanent teeth) · Individuals with permanent dentition in East Africa
Mean DMFT in Ethiopia was 1.182 (95% CI 1.135 to 1.229); certainty not graded.
1 finding from 1 review
Intervention not reported
Mean dmft (decayed, missing, filled primary teeth) · Children with primary dentition in East Africa
The pooled mean dmft (primary dentition) in East Africa was 2.237 (95% CI 1.293 to 3.181); certainty not graded.
1 finding from 1 review
Complications (e.g. discomfort, pain and swelling) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…
1 finding from 1 review
Changes in vertical height of alveolar ridge (mm) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…
It is very uncertain whether ARP with alloplast plus barrier membrane changes changes in vertical height of alveolar ridge (mm) compared with ARP with alloplast without membrane (very low certainty).
1 finding from 1 review