Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

2,434 questions in 139 reviews · Kidney and Transplant

current versions
No studies 504 · 20.7%Ungraded 40 · 1.6%Very low 611 · 25.1%Low 790 · 32.5%Moderate 414 · 17%High 75 · 3.1%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Prebiotic vs another prebiotic
Rumblings · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 24 participantsVery low
Prebiotic vs another prebiotic
Microbiota composition · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 24 participantsUngraded
Prebiotic vs another prebiotic
Actinobacteria · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 24 participantsUngraded
Prebiotic vs another prebiotic
Bacteriodetes · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 24 participantsUngraded
Synbiotic vs another synbiotic
Indoxyl sulfate · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Prebiotic vs another prebiotic
Proteobacteria · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 24 participantsUngraded
Prebiotic vs another prebiotic
Firmicutes · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 24 participantsUngraded
Prebiotic vs another prebiotic
Synergistetes · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 24 participantsUngraded
Prebiotic vs another prebiotic
Verrucomicrobia · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 24 participantsUngraded
Prebiotic vs another prebiotic
Faecal acetate · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 24 participantsUngraded
Prebiotic vs another prebiotic
Faecal propionate · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 24 participantsUngraded
Prebiotic vs another prebiotic
Faecal butyrate · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 24 participantsUngraded
Prebiotic vs another prebiotic
Faecal total short‐chain fatty acids · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 24 participantsUngraded
Prebiotic vs another prebiotic
Faecal indoles · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 24 participantsUngraded
Prebiotic vs another prebiotic
Faecal P‐cresol · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 24 participantsUngraded
Synbiotic vs another synbiotic
Change in any GI upset or intolerance · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Prebiotic vs another prebiotic
Graft function · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Prebiotic vs another prebiotic
Graft infection · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Prebiotic vs probiotic
eGFR · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Prebiotic vs probiotic
Albuminuria or proteinuria · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Prebiotic vs probiotic
Indoxyl sulfate · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Prebiotic vs probiotic
Change in any GI upset or intolerance · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Prebiotic vs probiotic
Microbiota composition · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Prebiotic vs probiotic
Graft function · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Prebiotic vs probiotic
Graft infection · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Probiotic vs another probiotic
eGFR (mL/min) · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 30 participantsVery low
Synbiotic vs another synbiotic
Microbiota composition · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Probiotic vs another probiotic
Albuminuria or proteinuria · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Probiotic vs another probiotic
Indoxyl sulfate · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Probiotic vs another probiotic
Change in any GI upset or intolerance · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Probiotic vs another probiotic
Microbiota composition · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Probiotic vs another probiotic
Graft function · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Probiotic vs another probiotic
Graft infection · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Synbiotic vs placebo or no treatment
eGFR (mL/min) · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted2 studies · 98 participantsVery low
Synbiotic vs placebo or no treatment
Albuminuria or proteinuria · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Synbiotic vs placebo or no treatment
Indoxyl sulfate · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Synbiotic vs placebo or no treatment
Change in any GI upset or intolerance (GSRS) · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 23 participantsVery low
Synbiotic vs another synbiotic
Graft function · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Synbiotic vs placebo or no treatment
Rumbling · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 23 participantsVery low
Synbiotic vs placebo or no treatment
Hard stools · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 23 participantsVery low
Synbiotic vs placebo or no treatment
Abdominal pain · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 23 participantsVery low
Synbiotic vs placebo or no treatment
Constipation syndrome · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted1 study · 23 participantsVery low
Synbiotic vs placebo or no treatment
Microbiota composition · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Synbiotic vs placebo or no treatment
Graft function · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Synbiotic vs placebo or no treatment
Graft infection · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Prebiotic vs placebo or no treatment
eGFR · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Prebiotic vs placebo or no treatment
Albuminuria or proteinuria · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Prebiotic vs placebo or no treatment
Indoxyl sulfate (mg/L) · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extracted2 studies · 75 participantsVery low
Synbiotic vs another synbiotic
Graft infection · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies
Prebiotic vs placebo or no treatment
Any change in GI upset or intolerance · people with CKD
Synbiotics, prebiotics and probiotics for people with chronic kidney disease (2023) · Cochrane
no estimate extractedNRNo studies