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Evidence found and GRADE certainty

503 questions · 676 findings · 22 reviews · Periodontology

No studies found 148 · 21.9%GRADE not reported 342 · 50.6%Very low 118 · 17.5%Low 45 · 6.7%Moderate 11 · 1.6%High 12 · 1.8%

Metronidazole + SRP vs Amoxicillin + metronidazole + SRP

Probing pocket depth · Adults with periodontitis (chronic and aggressive)

Metronidazole + SRP showed no clear difference in probing pocket depth compared with amoxicillin + metronidazole + SRP; GRADE not reported.

2 findings from 1 review

Metronidazole + SRP vs SRP

Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)

Metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with SRP; GRADE not reported.

3 findings from 1 review

Metronidazole + SRP vs Amoxicillin + metronidazole + SRP

Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive)

Metronidazole + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with amoxicillin + metronidazole + SRP; GRADE not reported.

2 findings from 1 review

Moxifloxacin + SRP vs SRP

Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis

Moxifloxacin + SRP led to lower percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.

2 findings from 1 review

Azithromycin + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether azithromycin + SRP changes adverse events compared with SRP (very low certainty).

1 finding from 1 review

Amoxicillin + metronidazole + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether amoxicillin + metronidazole + SRP changes adverse events compared with SRP (very low certainty).

1 finding from 1 review

Levofloxacin + SRP vs SRP

Clinical attachment level (CAL) · Adults with chronic periodontitis

Levofloxacin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.

2 findings from 1 review