Findings

What do systematic reviews say?

383 questions · 414 findings · 46 reviews · Hypertension

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No studies found 15 · 3.6%GRADE not reported 31 · 7.5%Very low 80 · 19.3%Low 148 · 35.7%Moderate 116 · 28%High 24 · 5.8%

Intervention not reported

Serum creatinine (mg/dL) · people with resistant hypertension

1 finding from 1 review

Renal denervation for resistant hypertension 2021 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 721 participants
Moderate

Intervention not reported

Ischaemic stroke · people with resistant hypertension

1 finding from 1 review

Renal denervation for resistant hypertension 2021 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 892 participants
Low

Intervention not reported

Unstable angina · people with resistant hypertension

1 finding from 1 review

Renal denervation for resistant hypertension 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 270 participants
Low

Intervention not reported

Hospitalisation · people with resistant hypertension

1 finding from 1 review

Renal denervation for resistant hypertension 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 743 participants
Low

Intervention not reported

Systolic 24‐hour ABPM (mmHg) · people with resistant hypertension

1 finding from 1 review

Renal denervation for resistant hypertension 2021 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 1045 participants
Moderate

Intervention not reported

Diastolic 24‐hour ABPM (mmHg) · people with resistant hypertension

1 finding from 1 review

Renal denervation for resistant hypertension 2021 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 1004 participants
Moderate

Intervention not reported

Systolic office BP (mmHg) · people with resistant hypertension

1 finding from 1 review

Renal denervation for resistant hypertension 2021 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 1090 participants
Moderate

Intervention not reported

Diastolic office BP (mmHg) · people with resistant hypertension

1 finding from 1 review

Renal denervation for resistant hypertension 2021 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 1049 participants
Moderate

Intervention not reported

eGFR or creatinine clearance (mL/min/1.73m²) · people with resistant hypertension

1 finding from 1 review

Renal denervation for resistant hypertension 2021 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 822 participants
Moderate

Lower blood pressure targets vs standard blood pressure targets

Total mortality · adult patients with hypertension

Lower BP target showed no clear difference in total mortality compared with standard BP target (high certainty).

1 finding from 1 review

Blood pressure targets in adults with hypertension 2020 · Cochrane Headline outcomes only
RR 0.95 [0.86, 1.05]
Studies not reported
High

Lower blood pressure targets vs standard blood pressure targets

Total serious adverse events№ of participants: 18165(6 RCTs) · adult patients with hypertension

Lower BP target showed no clear difference in total serious adverse events№ of participants: 18165(6 RCTs) compared with standard BP target (moderate certainty).

1 finding from 1 review

Blood pressure targets in adults with hypertension 2020 · Cochrane Headline outcomes only
RR 1.04 [0.99, 1.08]
Studies not reported
Moderate

Lower blood pressure targets vs standard blood pressure targets

Myocardial infarction · adult patients with hypertension

Lower BP target may leads to lower myocardial infarction№ of participants: 38,198(8 RCTs) compared with standard BP target (low certainty).

1 finding from 1 review

Blood pressure targets in adults with hypertension 2020 · Cochrane Headline outcomes only
RR 0.84 [0.73, 0.96]
Studies not reported
Low

Lower blood pressure targets vs standard blood pressure targets

Stroke · adult patients with hypertension

Lower BP target showed no clear difference in stroke№ of participants: 37,087(7 RCTs) compared with standard BP target (low certainty).

1 finding from 1 review

Blood pressure targets in adults with hypertension 2020 · Cochrane Headline outcomes only
RR 0.88 [0.77, 1.01]
Studies not reported
Low

Lower blood pressure targets vs standard blood pressure targets

Congestive heart failure · adult patients with hypertension

Lower BP target may leads to lower congestive heart failure№ of participants: 15,859(5 RCTs) compared with standard BP target (low certainty).

1 finding from 1 review

Blood pressure targets in adults with hypertension 2020 · Cochrane Headline outcomes only
RR 0.75 [0.6, 0.92]
Studies not reported
Low

Lower blood pressure targets vs standard blood pressure targets

Other serious adverse events · adult patients with hypertension

Lower BP target may leads to higher other serious adverse events compared with standard BP target (low certainty).

1 finding from 1 review

Blood pressure targets in adults with hypertension 2020 · Cochrane Headline outcomes only
RR 1.44 [1.32, 1.59]
Studies not reported
Low

Uric acid lowering therapies (UAR) vs placebo

24‐h ambulatory systolic BP · hyperuricaemia in people with hypertension

1 finding from 1 review

Pharmacotherapy for hyperuricaemia in hypertensive patients 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 229 participants
Low

Uric acid lowering therapies (UAR) vs placebo

24‐h ambulatory diastolic BP · hyperuricaemia in people with hypertension

1 finding from 1 review

Pharmacotherapy for hyperuricaemia in hypertensive patients 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 229 participants
Low

Uric acid lowering therapies (UAR) vs placebo

Systolic blood pressure · hyperuricaemia in people with hypertension

1 finding from 1 review

Pharmacotherapy for hyperuricaemia in hypertensive patients 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 120 participants
Low

Uric acid lowering therapies (UAR) vs placebo

Diastolic blood pressure · hyperuricaemia in people with hypertension

1 finding from 1 review

Pharmacotherapy for hyperuricaemia in hypertensive patients 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 120 participants
Low

Uric acid lowering therapies (UAR) vs placebo

Serum UA · hyperuricaemia in people with hypertension

1 finding from 1 review

Pharmacotherapy for hyperuricaemia in hypertensive patients 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 223 participants
High