Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

333 questions · 344 findings · 46 reviews

No studies found 90 · 26.2%GRADE not reported 24 · 7%Very low 80 · 23.3%Low 104 · 30.2%Moderate 37 · 10.8%High 9 · 2.6%

Autopolymerised sealant vs Light polymerised sealant

Development of >=1 new carious lesion (caries incidence) · Children with sound primary molars, aged 2-4 years (municipal dental clinics or hospital paediatric clinics, Denmark)

It is very uncertain whether autopolymerised sealant changes development of >=1 new carious lesion (caries incidence) compared with light polymerised sealant (very low certainty).

1 finding from 1 review

Glass ionomer-based sealant vs No sealant (control/no treatment)

Dental caries increment, DMFT/dmft (whole-tooth level) · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric clinic/dental school,…
1 finding from 1 review
  • Sealants for preventing dental caries in primary teeth 2022 · Cochrane All outcomes
    12 months
    Joshi 2019: dmft 8.43 (SD 5.84) with sealant vs 10.05 (SD 6.16) with no sealant at 12 months (caries threshold uncertain); Chadwick 2005: no significant difference in caries increment on occlusal surfaces, no summary…
    2 studies
    GRADE not reported

Antithrombin vs no thromboprophylaxis

Major bleeding · ambulatory paediatric cancer patients newly diagnosed with acute lymphoblastic leukaemia who received chemotherapy

It is very uncertain whether antithrombin changes major bleeding compared with no thromboprophylaxis (very low certainty).

1 finding from 1 review