Adverse events · Patients with active Crohn's disease
Azathioprine or 6‐mercaptopurine may leads to lower adverse events compared with methotrexate (low certainty).
1 finding from 1 review
Withdrawals due to adverse events · Patients with active Crohn's disease
It is very uncertain whether azathioprine or 6‐mercaptopurine changes withdrawals due to adverse events compared with methotrexate (very low certainty).
1 finding from 1 review
Oral mucositis (severe) · Patients with osteosarcoma (bone cancer) receiving high-dose methotrexate, vincristine and leucovorin
1 finding from 1 review
Oral mucositis (severe). Not estimable - no participants had developed severe oral mucositis by the fourth day after chemotherapy when the data were reported (Zhang 2011, Analysis 4.3, subgroup 3.2); 81 participants in…
1 study · 81 participants
GRADE not reported
Oral mucositis (severe) · Patients with osteosarcoma (bone cancer) receiving high-dose methotrexate, vincristine and leucovorin
1 finding from 1 review
Oral mucositis (severe). Not estimable - no participants had developed severe oral mucositis by the fourth day after chemotherapy when the data were reported (Zhang 2011, Analysis 4.3, subgroup 3.1); 118 participants…
1 study · 118 participants
GRADE not reported
Oral mucositis (any severity) · Patients with osteosarcoma (bone cancer) receiving high-dose methotrexate, vincristine and leucovorin
It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes oral mucositis (any severity) compared with low-dose leucovorin rinse (very low certainty).
1 finding from 1 review
Oral mucositis (moderate to severe) · Patients with osteosarcoma (bone cancer) receiving high-dose methotrexate, vincristine and leucovorin
It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes oral mucositis (moderate to severe) compared with low-dose leucovorin rinse (very low certainty).
1 finding from 1 review
Oral mucositis (any severity) · Patients with osteosarcoma (bone cancer) receiving high-dose methotrexate, vincristine and leucovorin
It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes oral mucositis (any severity) compared with high-dose leucovorin rinse (very low certainty).
1 finding from 1 review
Maintenance of remission · maintenance of remission in Crohn's disease
It is very uncertain whether 6‐Mercaptopurine changes maintenance of remission compared with methotrexate (very low certainty).
1 finding from 1 review
Adverse events · maintenance of remission in Crohn's disease
It is very uncertain whether 6‐Mercaptopurine changes adverse events compared with methotrexate (very low certainty).
1 finding from 1 review
Withdrawals due to adverse events · maintenance of remission in Crohn's disease
It is very uncertain whether 6‐Mercaptopurine changes withdrawals due to adverse events compared with methotrexate (very low certainty).
1 finding from 1 review
Serious adverse events · maintenance of remission in Crohn's disease
It is very uncertain whether 6‐Mercaptopurine changes serious adverse events compared with methotrexate (very low certainty).
1 finding from 1 review
Oral mucositis (moderate to severe) · Patients with osteosarcoma (bone cancer) receiving high-dose methotrexate, vincristine and leucovorin
1 finding from 1 review
Oral mucositis (moderate to severe). Not estimable - no participants had developed moderate or severe oral mucositis by the fourth day after chemotherapy when the data were reported (Zhang 2011, Analysis 4.2, subgroup…
1 study · 81 participants
GRADE not reported
Intervention not reported
ACR 50 American College of Rheumatology improvement criteria · patients with rheumatoid arthritis
The intervention probably leads to higher ACR 50 American College of Rheumatology improvement criteria (moderate certainty).
1 finding from 1 review
Intervention not reported
Remission3 · patients with rheumatoid arthritis
1 finding from 1 review
Intervention not reported
Functional Status Health Assessment Questionnaire Disability Index . Scale from: 0 to 3 · patients with rheumatoid arthritis
1 finding from 1 review
Intervention not reported
Health‐Related Quality of Life at least 20% improvement · patients with rheumatoid arthritis
The intervention showed no clear difference in health‐Related Quality of Life at least 20% improvement (moderate certainty).
1 finding from 1 review
Intervention not reported
Radiographic Progression Increase in erosion scores of > 3 units · patients with rheumatoid arthritis
The intervention probably leads to lower radiographic Progression Increase in erosion scores of > 3 units (moderate certainty).
1 finding from 1 review
Intervention not reported
Discontinuations due to adverse events · patients with rheumatoid arthritis
The intervention leads to higher discontinuations due to adverse events (high certainty).
1 finding from 1 review
Intervention not reported
Serious Adverse Events · patients with rheumatoid arthritis
The intervention showed no clear difference in serious Adverse Events (moderate certainty).
1 finding from 1 review
ASAS 40 · Patients with AS
The review found no eligible studies for this question.
1 finding from 1 review