Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether levamisole changes maximal mouth opening (interincisal distance) compared with antioxidant (Antoxid) (very low certainty).
2 findings from 1 review
Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Antioxidants (lycopene, curcumin, Oxitard) probably leads to lower burning sensation (VAS 0-100) compared with placebo or no active treatment (moderate certainty).
3 findings from 1 review
MD -70.82 [-94.39, -47.25]
2 studies · 500 participants
Moderate
MD -30.92 [-31.57, -30.27]
1 study · 400 participants
Moderate
MD -27.60 [-36.21, -18.99]
1 study · 90 participants
Moderate
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Antioxidants (lycopene, curcumin, Oxitard) showed no clear difference in maximal mouth opening (interincisal distance) compared with placebo or no active treatment (low certainty).
3 findings from 1 review
MD -1.41 [-5.74, 2.92]
1 study · 90 participants
Low
MD 3.11 [0.46, 5.77]
2 studies · 520 participants
Low
MD 8.83 [8.22, 9.45]
3 studies · 620 participants
Moderate
Range of mandibular motion · People with temporomandibular disorders (TMD)
Occlusal splint showed no clear difference in range of mandibular motion compared with pharmacological therapy; GRADE not reported.
1 finding from 1 review
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
Self-reported joint pain when chewing · People with temporomandibular disorders (TMD)
The review found no eligible studies for this question.
1 finding from 1 review
Difficulty in speech (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Pentoxifylline led to lower difficulty in speech (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.
1 finding from 1 review
Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
Sudarshan 2012 reported a reduction in burning sensation but no baseline data, so change could not be determined.
1 study · 20 participants
GRADE not reported
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
Discomfort/pain · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
The review found no eligible studies for this question.
1 finding from 1 review
Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether levamisole changes burning sensation (VAS 0-100) compared with antioxidant (Antoxid) (very low certainty).
2 findings from 1 review
Difficulty in swallowing (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Pentoxifylline led to lower difficulty in swallowing (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.
1 finding from 1 review
Muscle pain at rest · People with temporomandibular disorders (TMD)
The review found no eligible studies for this question.
1 finding from 1 review
Severity of joint noise · People with temporomandibular disorders (TMD)
It is very uncertain whether occlusal splint changes severity of joint noise compared with no treatment or placebo (non-occlusal or transparent-foil placebo… (very low certainty).
1 finding from 1 review
Depression · People with temporomandibular disorders (TMD)
Occlusal splint led to lower depression compared with no treatment or placebo (non-occlusal or transparent-foil placebo…; GRADE not reported.
1 finding from 1 review
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether jaw opening exercises alone changes maximal mouth opening (interincisal distance) compared with ultrasound plus jaw opening exercises (very low certainty).
1 finding from 1 review
Participant satisfaction or quality of life · People with temporomandibular disorders (TMD)
Occlusal splint led to lower participant satisfaction or quality of life compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.
1 finding from 1 review
Participant satisfaction or quality of life · People with temporomandibular disorders (TMD)
Occlusal splint showed no clear difference in participant satisfaction or quality of life compared with acupuncture; GRADE not reported.
1 finding from 1 review
Muscle pain when chewing · People with temporomandibular disorders (TMD)
It is very uncertain whether occlusal splint changes muscle pain when chewing compared with physical therapy (ultrasound, exercise, sensorimotor training,… (very low certainty).
1 finding from 1 review
Difficulty in speech (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Antioxidants (lycopene, curcumin, Oxitard) showed no clear difference in difficulty in speech (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.
1 finding from 1 review