Pain at 48 hours (VAS 0-10) · Adults (>18 years) with established dry socket following permanent tooth extraction
Topical anaesthetic gel (prilocaine-lidocaine) showed no clear difference in pain at 48 hours (VAS 0-10) compared with eugenol; GRADE not reported.
1 finding from 1 review
Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
Chlorhexidine gel (0.2%, intrasocket) showed no clear difference in presence of dry socket compared with chlorhexidine rinse (0.12%) (low certainty).
1 finding from 1 review
Healing of MRONJ (remission) · People with established (manifest) MRONJ
It is very uncertain whether teriparatide 56.5 microg weekly in addition to standard care changes healing of MRONJ (remission) compared with teriparatide 20 microg daily in addition to standard care (very low certainty).
1 finding from 1 review
Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
Tap water irrigation (monoject syringe) led to lower presence of dry socket compared with no rinsing; GRADE not reported.
1 finding from 1 review
Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
Chlorhexidine gel 1% showed no clear difference in presence of dry socket compared with chlorhexidine gel 0.2%; GRADE not reported.
1 finding from 1 review
MRONJ after tooth extraction (incidence proportion) · People on antiresorptive treatment undergoing tooth extraction (at risk of MRONJ)
Subperiosteal prepared (SPP) wound closure after tooth extraction showed no clear difference in MRONJ after tooth extraction (incidence proportion) compared with epiperiosteal prepared (EPP) wound closure after tooth extraction (low certainty).
1 finding from 1 review
Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
Honey (Manuka, topical) showed no clear difference in presence of dry socket compared with chlorhexidine rinse (0.2%); GRADE not reported.
1 finding from 1 review
Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
Chlorhexidine gel (0.2%, intrasocket) probably leads to lower presence of dry socket compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Quality of life · People with established (manifest) MRONJ
1 finding from 1 review
Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
Artemisia desertorum spreng (Shahaosan) showed no clear difference in presence of dry socket compared with artemisia desertorum spreng (Yunnan); GRADE not reported.
1 finding from 1 review
MRONJ (incidence proportion) · People with cancer treated with intravenous bisphosphonates undergoing dental extractions (at risk of MRONJ)
It is very uncertain whether dental extraction protocol with plasma rich in growth factors (PRGF)… changes MRONJ (incidence proportion) compared with standard dental extraction protocol without PRGF (very low certainty).
1 finding from 1 review
Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
Oral tissue patch led to lower presence of dry socket compared with placebo or control; GRADE not reported.
1 finding from 1 review
Time to initial pain relief (minutes) · Adults (>18 years) with established dry socket following permanent tooth extraction
Alvogyl led to lower time to initial pain relief (minutes) compared with zinc oxide eugenol; GRADE not reported.
1 finding from 1 review
MRONJ (incidence rate: cases per patient-year) · Men with metastatic prostate cancer receiving intravenous zoledronic acid (at risk of MRONJ)
It is very uncertain whether dental examinations at three-month intervals and preventive treatments changes MRONJ (incidence rate: cases per patient-year) compared with standard care (very low certainty).
1 finding from 1 review
Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
1 finding from 1 review
Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
1 finding from 1 review
Adverse effects · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)
1 finding from 1 review
Adverse effects were an outcome of interest in the study conducting this comparison, however no mention was made of the presence or absence of any adverse events
1 study · 220 participants
Very low
Incidence of ORN · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)
It is very uncertain whether hyperbaric oxygen therapy (HBO) following extractions changes incidence of ORN compared with perioperative antibiotic prophylaxis (penicillin G) following… (very low certainty).
1 finding from 1 review
Adverse effects (including quality of life) · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)
1 finding from 1 review
This comparison was only made in 1 study which reported no serious adverse events associated with HBO therapy. Quality of life measures (oral status, functioning, satisfaction) showed emotional functioning and pain…
1 study · 26 participants
Very low
Adverse effects · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)
1 finding from 1 review
Adverse effects were an outcome of interest in the study conducting this comparison, however no mention was made of the presence or absence of any adverse events
1 study · 74 participants
Very low