Findings

What do systematic reviews say?

418 questions · 423 findings · 44 reviews · Eyes and Vision

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No studies found 122 · 28.8%GRADE not reported 26 · 6.1%Very low 98 · 23.2%Low 120 · 28.4%Moderate 53 · 12.5%High 4 · 0.9%

Surgery vs botulinum neurotoxin injections

Adverse effects (severe, minor) at 6 months · children with infantile esotropia

1 finding from 1 review

Interventions for infantile esotropia 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 101 participants
Very low

Bilateral recession vs unilateral recession‐resection

Treatment success: improvement in the angle of strabismus at 6 months · children with infantile esotropia

1 finding from 1 review

Interventions for infantile esotropia 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 118 participants
Very low

Bilateral recession vs unilateral recession‐resection

Presence and quality of binocularity at 6 months · children with infantile esotropia

1 finding from 1 review

Interventions for infantile esotropia 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
Very low

Bilateral recession vs unilateral recession‐resection

Adverse effects (severe, minor) at 6 months · children with infantile esotropia

1 finding from 1 review

Interventions for infantile esotropia 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 118 participants
Very low

Systemic aminocaproic acid vs placebo

Short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment · people with traumatic hyphema

Systemic aminocaproic acid showed no clear difference in short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment compared with placebo (low certainty).

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
RR 0.87 [0.57, 1.32]
1 study · 34 participants
Low

Topical aminocaproic acid vs placebo

Long‐term visual acuity 20/40 or better > 2 months after treatment · people with traumatic hyphema

The review found no eligible studies for this question.

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical aminocaproic acid vs placebo

Final visual acuity 20/40 or better at resolution of hyphema · people with traumatic hyphema

The review found no eligible studies for this question.

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical aminocaproic acid vs placebo

Time to resolution of primary hemorrhage · people with traumatic hyphema

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 142 participants
Low

Topical aminocaproic acid vs placebo

Secondary hemorrhage at any time point · people with traumatic hyphema

Topical aminocaproic acid showed no clear difference in secondary hemorrhage at any time point compared with placebo (low certainty).

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
RR 0.48 [0.2, 1.1]
2 studies · 131 participants
Low

Topical aminocaproic acid vs placebo

Adverse effects: systemic hypotension · people with traumatic hyphema

The review found no eligible studies for this question.

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Systemic tranexamic acid vs control

Short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment · people with traumatic hyphema

Systemic tranexamic acid showed no clear difference in short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment compared with control (moderate certainty).

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
RR 1.12 [1, 1.25]
4 studies · 425 participants
Moderate

Systemic tranexamic acid vs control

Medium‐term visual acuity 20/40 or better > 2 weeks and ≤ 2 months after treatment · people with traumatic hyphema

The review found no eligible studies for this question.

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Systemic tranexamic acid vs control

Long‐term visual acuity 20/40 or better > 2 months after treatment · people with traumatic hyphema

The review found no eligible studies for this question.

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Systemic tranexamic acid vs control

Final visual acuity 20/40 or better at resolution of hyphema · people with traumatic hyphema

The review found no eligible studies for this question.

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Systemic tranexamic acid vs control

Time to resolution of primary hemorrhage · people with traumatic hyphema

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 549 participants
Very low

Systemic aminocaproic acid vs placebo

Medium‐term visual acuity 20/40 or better > 2 weeks and ≤ 2 months after treatment · people with traumatic hyphema

The review found no eligible studies for this question.

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Systemic tranexamic acid vs control

Secondary hemorrhage at any time point · people with traumatic hyphema

Systemic tranexamic acid may leads to lower secondary hemorrhage at any time point compared with control (low certainty).

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
RR 0.33 [0.21, 0.53]
7 studies · 754 participants
Low

Systemic tranexamic acid vs control

Nausea · people with traumatic hyphema

The review found no eligible studies for this question.

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Systemic or topical corticosteroids vs placebo or control

Short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after treatment; oral corticosteroids · people with traumatic hyphema

Systemic or topical corticosteroids showed no clear difference in short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after… compared with placebo or control treatment (low certainty).

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
RR 1.2 [0.97, 1.49]
2 studies · 277 participants
Low

Systemic or topical corticosteroids vs placebo or control

Final visual acuity between 20/20 and 20/40 at end of treatment; oral corticosteroids · people with traumatic hyphema

Systemic or topical corticosteroids showed no clear difference in final visual acuity between 20/20 and 20/40 at end of treatment;… compared with placebo or control treatment (low certainty).

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
RR 1.01 [0.84, 1.23]
1 study · 41 participants
Low