Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

313 questions · 352 findings · 23 reviews · Drugs and Alcohol

No studies found 16 · 4.5%GRADE not reported 34 · 9.7%Very low 113 · 32.1%Low 117 · 33.2%Moderate 57 · 16.2%High 15 · 4.3%

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF) (manualized) vs other clinical interventions

Abstinence · adults (> 18 years) with alcohol use disorder, alcohol abuse, or alcohol dependence

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF) (manualized) leads to higher abstinence compared with other clinical interventions (high certainty).

2 findings from 1 review

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF) (manualized) vs other clinical interventions

Drinking Intensity · adults (> 18 years) with alcohol use disorder, alcohol abuse, or alcohol dependence
2 findings from 1 review

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF) (manualized) vs other clinical interventions

Alcohol‐related consequences · adults (> 18 years) with alcohol use disorder, alcohol abuse, or alcohol dependence
2 findings from 1 review

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF) (manualized) vs other clinical interventions

Addiction Severity Index alcohol score · adults (> 18 years) with alcohol use disorder, alcohol abuse, or alcohol dependence
2 findings from 1 review

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF) (non‐manualized) vs other clinical interventions

Abstinence · adults (> 18 years) with alcohol use disorder, alcohol abuse, or alcohol dependence

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF)… showed no clear difference in abstinence compared with other clinical interventions (low certainty).

1 finding from 1 review

Integrated CBT vs Twelve Step Facilitation

Depression score · co‐occurring depression and substance use disorders
2 findings from 1 review

Integrated CBT vs Twelve Step Facilitation

Percent of days abstinent · co‐occurring depression and substance use disorders
2 findings from 1 review