Intervention not reported
Non‐fatal macrovascular outcomes 1. Composite 2. Non‐fatal myocardial infarction Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus
The intervention showed no clear difference in non‐fatal macrovascular outcomes 1. Composite 2. Non‐fatal… (low certainty).
1 finding from 1 review
RR 1.08 [0.81, 1.45]
1 study · 2 participants
Low
Intervention not reported
Cancer Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus
The intervention showed no clear difference in cancer Intervention vs insulin [4.75 years to 10.0 years] (low certainty).
1 finding from 1 review
Intervention not reported
All‐cause mortality a. Intervention vs metformin [a. 24 weeks to 4 years] b. Intervention vs thiazolidinediones [b. 24 weeks to 4 years] c. Intervention vs insulin [c. 9 months to 10 years] d. Intervention vs incretin‐based control [d. 52 weeks to... · participants with type 2 diabetes mellitus
The intervention showed no clear difference in all‐cause mortality a. Intervention vs metformin [a. 24 weeks to 4… (low certainty).
1 finding from 1 review
Intervention not reported
Cardiovascular mortality a. Intervention vs metformin [a. 24 weeks to 4 years] b. Intervention vs thiazolidinediones [b. 24 weeks to 4 years] c. Intervention vs insulin [c. 9 months to 10 years] d. Intervention vs meglitinide [d. 12 months to 17 m... · participants with type 2 diabetes mellitus
The intervention showed no clear difference in cardiovascular mortality a. Intervention vs metformin [a. 24 weeks… (low certainty).
1 finding from 1 review
Macrosomia · pregnant women with pre‐existing diabetes
1 finding from 1 review
Perinatal mortality · pregnant women with pre‐existing diabetes
1 finding from 1 review
Pre‐eclampsia · pregnant women with pre‐existing diabetes
It is very uncertain whether lispro changes pre‐eclampsia compared with regular insulin (Different insulin types within similar insulin… (very low certainty).
1 finding from 1 review
Caesarean section · pregnant women with pre‐existing diabetes
It is very uncertain whether lispro changes caesarean section compared with regular insulin (Different insulin types within similar insulin… (very low certainty).
1 finding from 1 review
Fetal anomaly · pregnant women with pre‐existing diabetes
It is very uncertain whether lispro changes fetal anomaly compared with regular insulin (Different insulin types within similar insulin… (very low certainty).
1 finding from 1 review
Birth trauma including shoulder dystocia, nerve palsy, or fracture · pregnant women with pre‐existing diabetes
1 finding from 1 review
Composite outcome measure of neonatal morbidity · pregnant women with pre‐existing diabetes
1 finding from 1 review
Intervention not reported
Incidence of type 2 diabetes mellitus · non‐diabetic adults with insulin resistance
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Diabetic complications · non‐diabetic adults with insulin resistance
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Adverse events · non‐diabetic adults with insulin resistance
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Health‐related quality of life · non‐diabetic adults with insulin resistance
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
All‐cause mortality · non‐diabetic adults with insulin resistance
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Socioeconomic effects · non‐diabetic adults with insulin resistance
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
HbA1c (glycated haemoglobin), change · children over 12 and adults with CFRD
Summary of findings: repaglinide showed no clear difference in hbA1c (%) change from baseline compared with insulin (high certainty).
1 finding from 1 review
FEV1 (% predicted): mean change from baseline · children over 12 and adults with CFRD
Summary of findings: repaglinide showed no clear difference in FEV1 % predicted change from baseline compared with insulin (moderate certainty).
1 finding from 1 review
FVC (% predicted) Change from baseline · children over 12 and adults with CFRD
Summary of findings: repaglinide showed no clear difference in FVC % predicted change from baseline compared with insulin (moderate certainty).
1 finding from 1 review