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Evidence found and GRADE certainty

396 questions · 408 findings · 34 reviews

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No studies found 113 · 27.7%GRADE not reported 40 · 9.8%Very low 91 · 22.3%Low 105 · 25.7%Moderate 50 · 12.3%High 9 · 2.2%

Intervention not reported

Cardiovascular mortality a. Intervention vs placebo [30 weeks to 4.75 years] b. Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus

The intervention may leads to higher cardiovascular mortality a. Intervention vs placebo [30 weeks to… (low certainty).

1 finding from 1 review

Intervention not reported

Non‐fatal macrovascular outcomes 1. Composite 2. Non‐fatal myocardial infarction Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus

The intervention showed no clear difference in non‐fatal macrovascular outcomes 1. Composite 2. Non‐fatal… (low certainty).

1 finding from 1 review

Intervention not reported

Cancer Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus

The intervention showed no clear difference in cancer Intervention vs insulin [4.75 years to 10.0 years] (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality a. Intervention vs metformin [a. 24 weeks to 4 years] b. Intervention vs thiazolidinediones [b. 24 weeks to 4 years] c. Intervention vs insulin [c. 9 months to 10 years] d. Intervention vs incretin‐based control [d. 52 weeks to... · participants with type 2 diabetes mellitus

The intervention showed no clear difference in all‐cause mortality a. Intervention vs metformin [a. 24 weeks to 4… (low certainty).

1 finding from 1 review

Intervention not reported

Cardiovascular mortality a. Intervention vs metformin [a. 24 weeks to 4 years] b. Intervention vs thiazolidinediones [b. 24 weeks to 4 years] c. Intervention vs insulin [c. 9 months to 10 years] d. Intervention vs meglitinide [d. 12 months to 17 m... · participants with type 2 diabetes mellitus

The intervention showed no clear difference in cardiovascular mortality a. Intervention vs metformin [a. 24 weeks… (low certainty).

1 finding from 1 review

Lispro vs regular insulin (Different insulin types within similar insulin regimens)

Pre‐eclampsia · pregnant women with pre‐existing diabetes

It is very uncertain whether lispro changes pre‐eclampsia compared with regular insulin (Different insulin types within similar insulin… (very low certainty).

1 finding from 1 review

Lispro vs regular insulin (Different insulin types within similar insulin regimens)

Caesarean section · pregnant women with pre‐existing diabetes

It is very uncertain whether lispro changes caesarean section compared with regular insulin (Different insulin types within similar insulin… (very low certainty).

1 finding from 1 review

Lispro vs regular insulin (Different insulin types within similar insulin regimens)

Fetal anomaly · pregnant women with pre‐existing diabetes

It is very uncertain whether lispro changes fetal anomaly compared with regular insulin (Different insulin types within similar insulin… (very low certainty).

1 finding from 1 review