Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

227 questions · 258 findings · 32 reviews

No studies found 68 · 26.4%GRADE not reported 32 · 12.4%Very low 47 · 18.2%Low 70 · 27.1%Moderate 34 · 13.2%High 7 · 2.7%

Constraint induced movement therapy (CIMT) vs high‐dose comparison

Unimanual capacity · children with unilateral cerebral palsy
2 findings from 1 review

Combined spinal‐epidural vs high‐dose spinal

Number of women requiring a repeat regional block or a general anaesthetic as a result of failure to establish adequate initial blockade · women undergoing caesarean section

Combined spinal‐epidural showed no clear difference in number of women requiring a repeat regional block or a general… compared with high‐dose spinal (low certainty).

1 finding from 1 review

Combined spinal‐epidural vs high‐dose spinal

Number of women requiring supplemental intra‐operative analgesia at any time after CSE or spinal anaesthetic insertion · women undergoing caesarean section

It is very uncertain whether combined spinal‐epidural changes number of women requiring supplemental intra‐operative analgesia at… compared with high‐dose spinal (very low certainty).

1 finding from 1 review

Combined spinal‐epidural vs high‐dose spinal

Number of women requiring intra‐operative conversion to general anaesthesia · women undergoing caesarean section

It is very uncertain whether combined spinal‐epidural changes number of women requiring intra‐operative conversion to general… compared with high‐dose spinal (very low certainty).

1 finding from 1 review

Low‐dose opioid based general anaesthesia vs high‐dose opioid based general anaesthesia

Mortality ‐ Death at any time after surgery · adult cardiac surgical patients

Low‐dose opioid‐based GA showed no clear difference in mortality ‐ Death at any time after surgery compared with high‐dose opioid‐based GA (low certainty).

1 finding from 1 review

Low‐dose opioid based general anaesthesia vs high‐dose opioid based general anaesthesia

Postoperative complications ‐ Myocardial infarction · adult cardiac surgical patients

Low‐dose opioid‐based GA showed no clear difference in postoperative myocardial infarction compared with high‐dose opioid‐based GA (low certainty).

1 finding from 1 review