Intervention not reported
All cause AEs ‐ MD TRIPLE vs HD‐ICS/LABA№ of participants: 2659(2 RCTs)
The intervention showed no clear difference in all cause AEs ‐ MD TRIPLE vs HD‐ICS/LABA№ of participants: 2659(2… (low certainty).
1 finding from 1 review
Intervention not reported
All cause AEs ‐ HD TRIPLE vs HD‐ICS/LABA№ of participants: 5004(4 RCTs)
The intervention leads to lower all cause AEs ‐ HD TRIPLE vs HD‐ICS/LABA№ of participants: 5004(4… (high certainty).
1 finding from 1 review
Intervention not reported
All cause AEs ‐ HD TRIPLE vs MD TRIPLE№ of participants: 3473(3 RCTs)
The intervention showed no clear difference in all cause AEs ‐ HD TRIPLE vs MD TRIPLE№ of participants: 3473(3 RCTs) (moderate certainty).
1 finding from 1 review
Intervention not reported
All cause AEs ‐ TRIPLE vs DUAL№ of participants: 8192(6 RCTs)
The intervention leads to lower all cause AEs ‐ TRIPLE vs DUAL№ of participants: 8192(6 RCTs) (high certainty).
1 finding from 1 review
Intervention not reported
Moderate to severe exacerbations ‐ HD‐ICS/LABA vs MD‐ICS/LABA№ of participants: 5452(6 RCTs)
The intervention showed no clear difference in moderate to severe exacerbations ‐ HD‐ICS/LABA vs MD‐ICS/LABA№ of… (high certainty).
1 finding from 1 review
Intervention not reported
Dropouts due to adverse event ‐ HD‐ICS/LABA vs MD‐ICS LABA№ of participants: 5969(7 RCTs)
The intervention showed no clear difference in dropouts due to adverse event ‐ HD‐ICS/LABA vs MD‐ICS LABA№ of… (high certainty).
1 finding from 1 review
Intervention not reported
Dropouts due to adverse event ‐ MD TRIPLE vs MD‐ICS/LABA№ of participants: 3205(3 RCTs)
It is very uncertain whether the intervention changes dropouts due to adverse event ‐ MD TRIPLE vs MD‐ICS/LABA№ of… (very low certainty).
1 finding from 1 review
Intervention not reported
Dropouts due to adverse event ‐ HD TRIPLE vs MD‐ICS/LABA№ of participants: 2670(2 RCTs)
The intervention showed no clear difference in dropouts due to adverse event ‐ HD TRIPLE vs MD‐ICS/LABA№ of… (moderate certainty).
1 finding from 1 review
Intervention not reported
Dropouts due to adverse event ‐ MD TRIPLE vs HD‐ICS/LABA№ of participants: 2668(2 RCTs)
The intervention showed no clear difference in dropouts due to adverse event ‐ MD TRIPLE vs HD‐ICS/LABA№ of… (moderate certainty).
1 finding from 1 review
Intervention not reported
Dropouts due to adverse event ‐ HD TRIPLE vs HD‐ICS/LABA№ of participants: 5018(4 RCTs)
The intervention leads to lower dropouts due to adverse event ‐ HD TRIPLE vs HD‐ICS/LABA№ of… (high certainty).
1 finding from 1 review
Intervention not reported
Dropouts due to adverse event ‐ HD TRIPLE vs MD TRIPLE№ of participants: 1765(2 RCTs)
The intervention showed no clear difference in dropouts due to adverse event ‐ HD TRIPLE vs MD TRIPLE№ of… (moderate certainty).
1 finding from 1 review
Intervention not reported
Dropouts due to adverse event ‐ TRIPLE vs DUAL№ of participants: 8223(5 RCTs)
The intervention showed no clear difference in dropouts due to adverse event ‐ TRIPLE vs DUAL№ of participants:… (moderate certainty).
1 finding from 1 review
Intervention not reported
Total studies: 11 RCTs Total Participants: 13209 · Adolescent sand adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…
1 finding from 1 review
Intervention not reported
HD‐ICS/LABA (Direct evidence; 6 RCTs; 6244 participants) · Adolescent sand adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…
1 finding from 1 review
Intervention not reported
MD‐TRIPLE (Direct evidence; 3 RCTs; 3188 participants) · Adolescent sand adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…
1 finding from 1 review
Intervention not reported
Moderate to severe exacerbations ‐ MD TRIPLE vs MD‐ICS/LABA№ of participants: 3184(3 RCTs)
The intervention probably leads to lower moderate to severe exacerbations ‐ MD TRIPLE vs MD‐ICS/LABA№ of… (moderate certainty).
1 finding from 1 review
Intervention not reported
HD‐TRIPLE (Direct evidence; 2 RCTs; 2039 participants) · Adolescent sand adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…
1 finding from 1 review
Intervention not reported
MD‐ICS/LABA · Adolescent sand adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Total studies: 12 RCTs Total Participants: 12915 · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…
1 finding from 1 review
Intervention not reported
HD‐ICS/LABA (Direct evidence; 7 RCTs; 5949 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…
1 finding from 1 review