First‐line chemotherapy vs BSC
- Chemotherapy versus best supportive care for extensive small cell lung cancer 2013 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 65 participantsVery low
Maintenance chemotherapy showed no clear difference in 3‐year PFS compared with observation (moderate certainty).
Maintenance chemotherapy showed no clear difference in 3‐year PFS compared with maintenance radiotherapy (low certainty).
Maintenance chemotherapy showed no clear difference in 3‐year OS compared with maintenance radiotherapy (low certainty).
Maintenance chemotherapy showed no clear difference in 5‐year OS compared with maintenance radiotherapy (low certainty).
Maintenance chemotherapy showed no clear difference in 10‐year OS compared with maintenance radiotherapy (low certainty).
Maintenance chemotherapy showed no clear difference in 3‐year OS compared with observation (moderate certainty).
Maintenance chemotherapy showed no clear difference in 5‐year OS compared with observation (moderate certainty).
Maintenance chemotherapy showed no clear difference in 10‐year OS compared with observation (moderate certainty).
Summary of findings table (subcomparison 2): second‐line… probably leads to lower overall survival compared with control intervention alone (moderate certainty).
Summary of findings table (subcomparison 2): second‐line… may leads to lower progression‐free survival compared with control intervention alone (low certainty).
It is very uncertain whether summary of findings table (subcomparison 2): second‐line… changes toxicity compared with control intervention alone (very low certainty).
Post‐surgical chemotherapy leads to lower overall Survival (OS) compared with surgery alone (high certainty).
Post‐surgical chemotherapy leads to lower disease Free Survival compared with surgery alone (high certainty).
Anti‐EGFR antibody plus chemotherapy showed no clear difference in overall survival compared with chemotherapy alone (moderate certainty).
Anti‐EGFR antibody plus chemotherapy showed no clear difference in progression‐free survival compared with chemotherapy alone (low certainty).
Anti‐EGFR antibody plus chemotherapy showed no clear difference in toxicity: grade 3 to 4 anaemia compared with chemotherapy alone (low certainty).
It is very uncertain whether anti‐EGFR antibody plus chemotherapy changes toxicity: grade 3 or 4 diarrhoea compared with chemotherapy alone (very low certainty).