Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

270 questions · 320 findings · 28 reviews

No studies found 58 · 18.1%GRADE not reported 96 · 30%Very low 86 · 26.9%Low 55 · 17.2%Moderate 16 · 5%High 9 · 2.8%

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Service utilisation (1 to 6 months post intervention) ‐ incidence of visits to primary care centres due to alcohol consumption (RR > 1 denotes greater risk) · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether primary health professional‐ and community professional‐led… changes service utilisation (1 to 6 months post intervention) ‐ incidence of… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Adverse events (1 to 6 months post intervention) ‐ incidence of alcohol‐related consequences ‐ accidents (RR > 1 denotes greater risk) · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether primary health professional‐ and community professional‐led… changes adverse events (1 to 6 months post intervention) ‐ incidence of… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Clinical recovery ‐ harmful or dependent alcohol use (1 to 6 months post intervention) Defined by AUDIT score < 8 (RR > 1 denotes higher likelihood of recovery) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes clinical recovery ‐ harmful or dependent alcohol use (1 to 6 months… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Clinical symptoms ‐ alcohol use (1 to 6 months post intervention) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes clinical symptoms ‐ alcohol use (1 to 6 months post intervention) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Clinical symptoms ‐ depression (1 to 6 months post intervention) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes clinical symptoms ‐ depression (1 to 6 months post intervention) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Functional impairment · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes functional impairment (1 to 6 months post intervention) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Service utilisation ‐ Unplanned hospitalisation in past 12 months (RR > 1 denotes higher risk of hospitalisation) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes service utilisation ‐ Unplanned hospitalisation in past 12 months… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Adverse events ‐ death in past 12 months (RR > 1 denotes higher risk of death) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes adverse events ‐ death in past 12 months (RR > 1 denotes higher risk… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Prevalence of morphine use · adult patients with substance dependence

It is very uncertain whether primary health professional‐ and community professional‐led… changes prevalence of morphine use compared with enhanced usual care (very low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Clinical symptoms ‐ alcohol use (1 to 6 months post intervention) · adult patients with substance dependence

It is very uncertain whether primary health professional‐ and community professional‐led… changes clinical symptoms ‐ alcohol use (< 1 month post intervention) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Clinical symptoms ‐ drug use (< 1 month post intervention) ‐ heroin · adult patients with substance dependence

It is very uncertain whether primary health professional‐ and community professional‐led… changes clinical symptoms ‐ drug use (< 1 month post intervention) ‐ heroin compared with enhanced usual care (very low certainty).

1 finding from 1 review

Radiographic imaging methods (any: analogue radiographs, digital radiographs, or CBCT) vs Reference standard (histology, excavation, or enhanced visual examination)

Diagnostic accuracy on surfaces with pit and fissure sealants · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…

The review found no eligible studies for this question.

1 finding from 1 review
  • Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomes
    Up to 3 months between index test and reference standard (in vivo studies) · Pit and fissure sealants
    Pre-specified heterogeneity investigation of surfaces with pit and fissure sealants: no study reported the inclusion of sealants that would allow evaluation of early caries lesions.
    0 studies
    No studies found

Near-infrared (NIR) transillumination vs Reference standard (histology, excavation, radiographs/microCT, or tooth separation)

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review