Findings

What do systematic reviews say?

6 questions · 6 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 1 · 16.7%Very low 1 · 16.7%Low 2 · 33.3%Moderate 1 · 16.7%High 1 · 16.7%

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

Selective serotonin reuptake inhibitors may leads to lower failure to respond compared with placebo (low certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.75 [0.67, 0.84]
21 studies · 4000 participants
Low

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

It is very uncertain whether SSRIs changes failure to respond compared with benzodiazepines (very low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 0.93 [0.48, 1.8]
1 study · 154 participants
Very low

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

SSRIs showed no clear difference in failure to respond compared with MAOIs (moderate certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.12 [0.83, 1.52]
2 studies · 396 participants
Moderate

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

SSRIs showed no clear difference in failure to respond compared with SNRIs (high certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 0.96 [0.75, 1.23]
2 studies · 991 participants
High

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

TCAs showed no clear difference in failure to respond compared with SSRI (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.08 [0.71, 1.66]
4 studies · 438 participants
Low