Findings

What do systematic reviews say?

6 questions · 6 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 1 · 16.7%Very low 1 · 16.7%Low 0 · 0%Moderate 3 · 50%High 1 · 16.7%

Failure to remit at endpoint · adults with panic disorder

Selective serotonin reuptake inhibitors probably leads to lower failure to remit compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.81 [0.75, 0.88]
16 studies · 3339 participants
Moderate

Failure to remit at endpoint · adults with panic disorder

It is very uncertain whether SSRIs changes failure to remit compared with benzodiazepines (very low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.12 [0.79, 1.59]
1 study · 154 participants
Very low

Failure to remit at endpoint · adults with panic disorder

SSRIs showed no clear difference in failure to remit compared with MAOIs (moderate certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 0.93 [0.74, 1.17]
1 study · 366 participants
Moderate

Failure to remit at endpoint · adults with panic disorder

SSRIs showed no clear difference in failure to remit compared with SNRIs (high certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.05 [0.91, 1.21]
2 studies · 991 participants
High

Failure to remit at endpoint · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Failure to remit at endpoint · adults with panic disorder

TCAs showed no clear difference in failure to remit compared with SSRI (moderate certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 0.89 [0.63, 1.26]
5 studies · 475 participants
Moderate