What do systematic reviews say?

Antidepressants vs placebo

Antidepressants probably leads to lower failure to remit compared with placebo (moderate certainty).

• Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
  RR 0.83 [0.78, 0.88]
  24 studies · 6164 participants
  Moderate

Antidepressants vs benzodiazepines

Antidepressants probably leads to higher failure to remit compared with benzodiazepines (moderate certainty).

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  RR 1.18 [1.01, 1.37]
  3 studies · 1002 participants
  Moderate

Tricyclic antidepressants vs placebo

Tricyclic antidepressants may leads to lower failure to remit compared with placebo (low certainty).

• Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
  RR 0.82 [0.69, 0.99]
  8 studies · 1294 participants
  Low

Selective serotonin reuptake inhibitors vs placebo

Selective serotonin reuptake inhibitors probably leads to lower failure to remit compared with placebo (moderate certainty).

• Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
  RR 0.81 [0.75, 0.88]
  16 studies · 3339 participants
  Moderate

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Serotonin‐norepinephrine reuptake inhibitors probably leads to lower failure to remit compared with placebo (moderate certainty).

• Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
  RR 0.84 [0.75, 0.95]
  4 studies · 1531 participants
  Moderate

Selective serotonin reuptake inhibitors vs benzodiazepines

It is very uncertain whether SSRIs changes failure to remit compared with benzodiazepines (very low certainty).

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  RR 1.12 [0.79, 1.59]
  1 study · 154 participants
  Very low

Tricyclic antidepressants vs SSRI

TCAs showed no clear difference in failure to remit compared with SSRI (moderate certainty).

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  RR 0.89 [0.63, 1.26]
  5 studies · 475 participants
  Moderate

Tricyclic antidepressants vs MAOI

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Selective serotonin reuptake inhibitors vs MAOI

SSRIs showed no clear difference in failure to remit compared with MAOIs (moderate certainty).

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  RR 0.93 [0.74, 1.17]
  1 study · 366 participants
  Moderate

Selective serotonin reuptake inhibitors vs SNRIs

SSRIs showed no clear difference in failure to remit compared with SNRIs (high certainty).

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  RR 1.05 [0.91, 1.21]
  2 studies · 991 participants
  High

Selective serotonin reuptake inhibitors vs NaSSAs

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Tricyclic antidepressants vs benzodiazepines

TCAs showed no clear difference in failure to remit compared with benzodiazepines (moderate certainty).

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  RR 1.19 [1, 1.41]
  2 studies · 848 participants
  Moderate