What do systematic reviews say?

DPP4i vs placebo

DPP4i showed no clear difference in worsening renal function compared with placebo (low certainty).

• Dipeptidyl peptidase‐4 inhibitors, glucagon‐like peptide 1 receptor agonists and sodium‐glucose co‐transporter‐2… 2021 · Cochrane Headline outcomes only
  OR 1.08 [0.88, 1.33]
  1 study · 16492 participants
  Low