What do systematic reviews say?

5 questions · 5 findings · 4 reviews · Hypertension

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 40%Low 2 · 40%Moderate 1 · 20%High 0 · 0%

Closest answers

The findings closest to your search, judged one by one by TypeSafe's Jev model.

Direct match · question page
- All doses of cerivastatin vs placebo · Withdrawals due to adverse events
  Cerivastatin for lowering lipids 2020 · Cochrane Headline outcomes only
  RR 1.09 [0.68, 1.74]
  11 studies · 6570 participants
  Very low
Direct match · question page
- Evening vs morning dosing regimen · Withdrawals from treatment due to adverse events
  Evening versus morning dosing regimen drug therapy for hypertension 2024 · Cochrane Headline outcomes only
  RR 0.76 [0.47, 1.23]
  7 studies · 1777 participants
  Very low
Direct match · question page
- Uric acid‐lowering drug vs placebo · Adverse events (withdrawals due to side effects)
  Pharmacotherapy for hyperuricaemia in hypertensive patients 2020 · Cochrane Headline outcomes only
  RR 1.86 [0.43, 8.1]
  3 studies · 241 participants
  Low
Direct match · question page
- Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs Supra-gingival scaling · Adverse events (participants with adverse events or withdrawals due to adverse events)
  Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes
  SoF 2 (Adverse effects): 3 studies reported no adverse effects. 328 (3 studies); Moderate.
  3 studies · 328 participants
  Moderate
Direct match · question page
- Periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment) · Adverse events (participants with adverse events or withdrawals due to adverse events)
  Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes
  SoF 1 (Adverse effects): Only 1 study reported that 1 participant in the treatment group experienced a myocardial infarction during the study period. 1 study reported no adverse effects. The remaining 2 studies did not…
  2 studies · 294 participants
  Low

All doses of cerivastatin vs placebo

Withdrawals due to adverse events · participants with normal or abnormal lipid profiles

It is very uncertain whether all doses of cerivastatin changes withdrawals due to adverse events compared with placebo (very low certainty).

1 finding from 1 review

Cerivastatin for lowering lipids 2020 · Cochrane Headline outcomes only
RR 1.09 [0.68, 1.74]
11 studies · 6570 participants
Very low

Evening vs morning dosing regimen

Withdrawals due to adverse events · adults with primary (essential) hypertension whose systolic or diastolic (or both) blood pressure levels were 130/80 mmHg or greater

It is very uncertain whether evening changes withdrawals from treatment due to adverse events compared with morning dosing regimen (very low certainty).

1 finding from 1 review

Evening versus morning dosing regimen drug therapy for hypertension 2024 · Cochrane Headline outcomes only
RR 0.76 [0.47, 1.23]
7 studies · 1777 participants
Very low

Uric acid lowering therapies (UAR) vs placebo

Withdrawals due to adverse events · hyperuricaemia in people with hypertension

Uric acid‐lowering drug showed no clear difference in adverse events (withdrawals due to side effects) compared with placebo (low certainty).

1 finding from 1 review

Pharmacotherapy for hyperuricaemia in hypertensive patients 2020 · Cochrane Headline outcomes only
RR 1.86 [0.43, 8.1]
3 studies · 241 participants
Low

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs Supra-gingival scaling

Adverse events (participants with adverse events or withdrawals due to adverse events) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

1 finding from 1 review

Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes
SoF 2 (Adverse effects): 3 studies reported no adverse effects. 328 (3 studies); Moderate.
3 studies · 328 participants
Moderate

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

1 finding from 1 review

Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes
SoF 1 (Adverse effects): Only 1 study reported that 1 participant in the treatment group experienced a myocardial infarction during the study period. 1 study reported no adverse effects. The remaining 2 studies did not…
2 studies · 294 participants
Low