Findings

What do systematic reviews say?

10 questions · 10 findings · 5 reviews · Headline outcomes only

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No studies found 2 · 20%GRADE not reported 0 · 0%Very low 3 · 30%Low 2 · 20%Moderate 2 · 20%High 1 · 10%

NSAIDs vs glucocorticoids

Withdrawals due to adverse events · acute gout

NSAIDs showed no clear difference in withdrawals due to adverse events compared with glucocorticoids (moderate certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
RR 2.8 [0.55, 14.22]
Studies not reported
Moderate

NSAIDs vs placebo

Withdrawals due to adverse events · acute gout

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

COX‐2 NSAIDs vs placebo

Withdrawals due to adverse events · patients with axSpA (AS and nr‐axSpA)

COX‐2 NSAIDs showed no clear difference in withdrawals due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and… 2015 · Cochrane Headline outcomes only
RR 2.14 [0.36, 12.56]
669 participants
Low

Traditional NSAIDs vs placebo

Withdrawals due to adverse events · patients with axSpA (AS and nr‐axSpA)

Traditional NSAIDs showed no clear difference in withdrawals due to adverse events Due to adverse events compared with placebo (high certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and… 2015 · Cochrane Headline outcomes only
RR 0.75 [0.46, 1.21]
1165 participants
High

Non‐selective NSAIDs vs selective cyclo‐oxygenase‐2 inhibitors

Withdrawals due to adverse events · acute gout

Non‐selective NSAIDs probably leads to higher withdrawals due to adverse events compared with selective cyclo‐oxygenase‐2 inhibitors (moderate certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
RR 2.34 [1.33, 4.14]
Studies not reported
Moderate

Low‐dose colchicine vs NSAIDs

Withdrawals due to adverse events · acute gout

The review found no eligible studies for this question.

1 finding from 1 review

Colchicine for acute gout 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Acupuncture vs NSAIDs

Withdrawals due to adverse events · patients with hip osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Acupuncture for hip osteoarthritis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Celecoxib vs naproxen

Withdrawals due to adverse events · children and adolescents with chronic non‐cancer pain

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 242 participants
Very low

Rofecoxib vs naproxen

Withdrawals due to adverse events · children and adolescents with chronic non‐cancer pain

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 310 participants
Very low

Meloxicam vs naproxen

Withdrawals due to adverse events · children and adolescents with chronic non‐cancer pain

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 225 participants
Very low