Findings

What do systematic reviews say?

9 questions · 9 findings · 1 reviews · Heart

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 44.4%Moderate 4 · 44.4%High 1 · 11.1%

Propafenone vs placebo or no treatment

Withdrawals due to adverse events · adults in sinus rhythm after cardioversion of atrial fibrillation

Propafenone probably leads to higher withdrawals due to adverse effects compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 1.62 [1.07, 2.46]
5 studies · 1098 participants
Moderate

Flecainide vs placebo or no treatment

Withdrawals due to adverse events · adults in sinus rhythm after cardioversion of atrial fibrillation

Flecainide showed no clear difference in withdrawals due to adverse effects compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 15.41 [0.91, 260]
1 study · 73 participants
Low

Quinidine vs placebo or no treatment

Withdrawals due to adverse events · adults in sinus rhythm after cardioversion of atrial fibrillation

Quinidine showed no clear difference in withdrawals due to adverse effects compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 1.56 [0.87, 2.78]
7 studies · 1669 participants
Moderate

Metoprolol vs placebo or no treatment

Withdrawals due to adverse events · adults in sinus rhythm after cardioversion of atrial fibrillation

Metoprolol leads to higher withdrawals due to adverse effects compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 3.47 [1.48, 8.1]
2 studies · 562 participants
High

Amiodarone vs placebo or no treatment

Withdrawals due to adverse events · adults in sinus rhythm after cardioversion of atrial fibrillation

Amiodarone may leads to higher withdrawals due to adverse effects compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 6.7 [1.91, 23.45]
4 studies · 319 participants
Low

Dofetilide vs placebo or no treatment

Withdrawals due to adverse events · adults in sinus rhythm after cardioversion of atrial fibrillation

Dofetilide showed no clear difference in withdrawals due to adverse effects compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 1.77 [0.75, 4.2]
2 studies · 677 participants
Low

Dronedarone vs placebo or no treatment

Withdrawals due to adverse events · adults in sinus rhythm after cardioversion of atrial fibrillation

Dronedarone probably leads to higher withdrawals due to adverse effects compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 1.58 [1.34, 1.85]
3 studies · 6071 participants
Moderate

Sotalol vs placebo or no treatment

Withdrawals due to adverse events · adults in sinus rhythm after cardioversion of atrial fibrillation

Sotalol probably leads to higher withdrawals due to adverse effects compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 1.95 [1.23, 3.11]
12 studies · 2688 participants
Moderate

Disopyramide vs placebo or no treatment

Withdrawals due to adverse events · adults in sinus rhythm after cardioversion of atrial fibrillation

Disopyramide showed no clear difference in withdrawals due to adverse effects compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 3.68 [0.95, 14.24]
2 studies · 146 participants
Low