What do systematic reviews say?

Nicotinamide vs clindamycin

Nicotinamide showed no clear difference in withdrawal for any reason (medium term: treatment duration from 5 to… compared with clindamycin (low certainty).

• Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
  RR 1.12 [0.49, 2.6]
  3 studies · 216 participants
  Low

Nicotinamide vs erythromycin

Nicotinamide showed no clear difference in withdrawal for any reason (medium term: treatment duration from 5 to… compared with erythromycin (low certainty).

• Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
  RR 1.4 [0.46, 4.22]
  1 study · 158 participants
  Low

Salicylic acid vs benzoyl peroxide

• Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 41 participants
  Very low

Salicylic acid vs pyruvic acid

Salicylic acid showed no clear difference in withdrawal for any reason (medium term: treatment duration from 5 to… compared with pyruvic acid (low certainty).

• Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
  RR 0.89 [0.53, 1.5]
  1 study · 86 participants
  Low