Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 16.7%Low 5 · 83.3%Moderate 0 · 0%High 0 · 0%

Azelaic acid vs clindamycin

Treatment withdrawal · participants with acne

Azelaic acid showed no clear difference in withdrawal for any reason (long term: treatment duration > 8 weeks) compared with clindamycin (low certainty).

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
RR 1.3 [0.48, 3.56]
2 studies · 329 participants
Low

Azelaic acid vs tretinoin

Treatment withdrawal · participants with acne

Azelaic acid showed no clear difference in withdrawal for any reason (long term: treatment duration > 8 weeks) compared with tretinoin (low certainty).

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
RR 0.66 [0.29, 1.47]
2 studies · 309 participants
Low

Azelaic acid vs adapalene

Treatment withdrawal · participants with acne

It is very uncertain whether azelaic acid changes withdrawal for any reason (long term: treatment duration > 8 weeks) compared with adapalene (very low certainty).

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
RR 2.64 [0.33, 20.99]
1 study · 55 participants
Very low

Salicylic acid vs tretinoin

Treatment withdrawal · participants with acne

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 74 participants
Low

Glycolic acid (alpha‐hydroxy acid) vs salicylic‐mandelic acid

Treatment withdrawal · participants with acne

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 84 participants
Low

Azelaic acid vs benzoyl peroxide

Treatment withdrawal · participants with acne

Azelaic acid showed no clear difference in withdrawal for any reason (long term: treatment duration > 8 weeks) compared with benzoyl peroxide (low certainty).

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
RR 0.88 [0.6, 1.29]
1 study · 351 participants
Low