Findings

What do systematic reviews say?

8 questions · 8 findings · 1 reviews · Tobacco Addiction

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No studies found 0 · 0%GRADE not reported 2 · 25%Very low 4 · 50%Low 2 · 25%Moderate 0 · 0%High 0 · 0%

Fast‐acting nicotine replacement therapy vs nicotine patch

Treatment withdrawal · people who smoke

It is very uncertain whether fast‐acting nicotine replacement therapy changes treatment withdrawals compared with nicotine patch (very low certainty).

1 finding from 1 review

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
RR 4.23 [1.54, 11.63]
3 studies · 1482 participants
Very low

Preloading nicotine replacement therapy (NRT) vs standard‐use NRT

Treatment withdrawal · people who smoke

It is very uncertain whether preloading nicotine replacement therapy (NRT) changes treatment withdrawals compared with standard‐use NRT (very low certainty).

1 finding from 1 review

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
RR 0.33 [0.01, 7.95]
1 study · 80 participants
Very low

Combination vs nicotine replacement therapy monotherapy

Treatment withdrawal · people who smoke

It is very uncertain whether combination changes treatment withdrawals compared with single‐form nicotine replacement therapy (very low certainty).

1 finding from 1 review

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
RR 1.12 [0.57, 2.2]
5 studies · 3070 participants
Very low

Longer vs shorter duration of combination nicotine replacement therapy

Treatment withdrawal · people who smoke

1 finding from 1 review

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Longer vs shorter duration of nicotine patch therapy

Treatment withdrawal · people who smoke

1 finding from 1 review

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 648 participants
Very low

Intervention not reported

Treatment withdrawals · people who smoke

1 finding from 1 review

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Higher‐dose vs lower‐dose nicotine patch

Treatment withdrawals ‐ 21 mg versus 14 mg (24‐hour patches) · people who smoke

Higher‐dose showed no clear difference in treatment withdrawals ‐ 21 mg versus 14 mg (24‐hour patches) compared with lower‐dose nicotine patch (low certainty).

1 finding from 1 review

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
RR 0.77 [0.36, 1.64]
1 study · 537 participants
Low

Higher‐dose vs lower‐dose nicotine patch

Treatment withdrawal · people who smoke

Higher‐dose may leads to higher treatment withdrawals ‐ 42/44 mg versus 21/22 mg (24‐hour patches) compared with lower‐dose nicotine patch (low certainty).

1 finding from 1 review

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
RR 4.99 [1.6, 15.5]
2 studies · 554 participants
Low