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What do systematic reviews say?

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Evidence found and GRADE certainty

5 questions · 5 findings · 4 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 40%Low 1 · 20%Moderate 2 · 40%High 0 · 0%

Gabapentin vs placebo

Treatment withdrawalNumber of participants withdrawn for any reason · people with drug‐resistant focal epilepsy

Gabapentin showed no clear difference in treatment withdrawalNumber of participants withdrawn for any reason compared with placebo (moderate certainty).

1 finding from 1 review

Vigabatrin vs placebo

Treatment withdrawal for any reason Duration of treatment (range): 12 (3 months) to 36 weeks · people (aged 10–64 years) with drug‐resistant focal epilepsy

It is very uncertain whether vigabatrin changes treatment withdrawal for any reason Duration of treatment (range):… compared with placebo (very low certainty).

1 finding from 1 review