What do systematic reviews say?

VGB vs CBZ monotherapy

VGB showed no clear difference in time to treatment withdrawal compared with CBZ monotherapy (low certainty).

• Vigabatrin versus carbamazepine monotherapy for epilepsy 2015 · Cochrane Headline outcomes only
  HR 0.75 [0.52, 1.1]
  1 study · 446 participants
  Low

Sulthiame vs placebo

• Sulthiame monotherapy for epilepsy 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 100 participants
  GRADE not reported

Sulthiame vs phenytoin

• Sulthiame monotherapy for epilepsy 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 146 participants
  GRADE not reported

Sulthiame vs levetiracetam

Sulthiame showed no clear difference in treatment withdrawal compared with levetiracetam (low certainty).

• Sulthiame monotherapy for epilepsy 2021 · Cochrane Headline outcomes only
  RR 0.32 [0.1, 1.03]
  1 study · 43 participants
  Low

Intervention not reported

The intervention may leads to higher time to treatment withdrawal ‐ all participants Range of (low certainty).

• Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures 2013 · Cochrane Headline outcomes only
  HR 1.62 [1.23, 2.14]
  3 studies · 499 participants
  Low

Intervention not reported

The intervention may leads to higher time to treatment withdrawal ‐ stratified by seizure type ‐ Partial… (low certainty).

• Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures 2013 · Cochrane Headline outcomes only
  HR 1.48 [1.1, 1.98]
  3 studies · 404 participants
  Low

Intervention not reported

The intervention may leads to higher time to treatment withdrawal ‐ stratified by seizure type ‐… (low certainty).

• Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures 2013 · Cochrane Headline outcomes only
  HR 4.04 [1.61, 10.14]
  2 studies · 95 participants
  Low